Publications by authors named "J H Widdicombe"

Echinococcosis is a zoonotic disease relevant to public health in many countries, on all continents except Antarctica. The objective of the study is to describe the registered cases and mortality from echinococcosis in Brazil, from 1995 to 2016. The records of two national databases, the Hospital Information System (HIS) and the Mortality Information System (MIS), were accessed during the period of 1995-2016.

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Article Synopsis
  • Cystic echinococcosis (CE) is a financially burdensome neglected tropical disease that affects 17 hyperendemic countries, with a goal set by the WHO to enhance control strategies by 2030.
  • A scoping review of existing literature was conducted, where 100 research papers were initially identified, leading to the final inclusion of 9 studies focused on the economic evaluations of CE control measures.
  • The findings revealed a significant lack of comprehensive cost data regarding CE interventions, indicating a crucial need for more detailed cost assessments to effectively analyze and improve these control measures in future research.
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Chronic bronchitis is associated with hypertrophy of airway submucosal glands and with mucus and squamous metaplasia of the surface epithelium. A historical review of research on these and other pathological changes is provided. Next, from annual reports of the Registrar-General's Office (and later the Office of National Statistics), death rates per unit population from acute and chronic bronchitis (a term that here includes chronic obstructive pulmonary disease [COPD]) are calculated for England and Wales from 1838 to the present.

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In this issue of Developmental Cell, Xie et al. show that in cystic fibrosis, airway gland mucus gels form under conditions of high acidity and protein concentration. This causes them to be unusually stiff.

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This article traces the beginnings of the various areas of physiological research on airway epithelium. First mentioned in 1600, it was not until 1834 that it was found to be ciliated. Goblet and basal cells were described in 1852, to be followed by ~10 other epithelial cell types (the most recent in 2018).

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