CRISPR/Cas13a-Programmed Cu NCs and -Scheme T-COF/AgS for Photoelectrochemical Biosensing of circRNA.

Circular RNAs (circRNAs), as a class of noncoding RNA molecules with a circular structure exhibit high stability and spatiotemporal-specific expression, making them ideal cancer biomarkers for liquid biopsy. Herein, a new photoelectrochemical (PEC) biosensor for a highly sensitive circRNA assay in the whole blood of lung cancer patients was designed based on CRISPR/Cas13a-programmed Cu nanoclusters (Cu NCs) and a -scheme covalent organic framework/silver sulfide (T-COF/AgS) composite. This -scheme T-COF/AgS composite accelerates electron transfer and produces an excellent initial photocurrent.

Insight into the Synergistic Effect of Binary Nonmetallic Codoped CoO Catalysts for Efficient Ethyl Acetate Degradation under Humid Conditions.

The synthesis of high-performance catalysts for volatile organic compounds (VOCs) degradation under humid conditions is essential for their practical industrial application. Herein, a codoping strategy was adopted to synthesize the N-CoO-C catalyst with N, C codoping for low-temperature ethyl acetate (EA) degradation under humid conditions. Results showed that N-CoO-C exhibited great catalytic activity ( = 177 °C) and water resistance (5.

Association between cardiovascular health and osteoporotic fractures: a national population-based study.

Osteoporotic fractures are a major public health concern, particularly among the aging population, as they significantly contribute to morbidity, mortality, and reduced quality of life. While cardiovascular health (CVH) has traditionally been linked to cardiovascular disease outcomes, emerging evidence suggests it may also influence bone health. This study investigates the association between CVH, as measured by the Life's Essential 8 (LE8) score, and the prevalence of osteoporotic fractures in U.

Profiling microRNA expression differentiates monozygotic twins in peripherical blood by droplet digital PCR.

It is challenging to distinguish monozygotic (MZ) twins using traditional autosomal STR genotyping due to their nearly identical genomes. As an important kind of small non-coding RNAs, microRNAs (miRNAs) are essential regulators of gene expression and considered as excellent biomarkers due to their resistance to degradation. Moreover, droplet digital PCR (ddPCR) has emerged as a powerful technique for detecting gene mutations and pathogenic microorganisms, owing to its sensitivity and reliability.