Publications by authors named "J H Terkelsen"
Article Synopsis
- The study aimed to create a porcine model to examine how moxifloxacin behaves in the central nervous system (CNS), particularly in brain extracellular fluid (ECF) and cerebrospinal fluid (CSF), after administering a single intravenous dose to pigs.
- Results showed that moxifloxacin concentrations in brain ECF were significantly lower than in plasma and lumbar CSF, suggesting ineffective penetration into the CNS for treating TB.
- Overall, the findings indicate that a single intravenous dose of moxifloxacin does not reach the necessary drug concentrations in the brain to effectively target TB, raising concerns for treatment in similar human cases.
Purpose: To evaluate patient demographics, surgery characteristics, and patient-reported clinical outcomes related to the implementation of lumbar PTED in Denmark by surgeons novice to the PTED technique.
Methods: All adult patients treated with a lumbar PTED from our first surgery in October 2020 to December 2021 were included. Data was generated by journal audit and telephone interview.
Patients with eosinophilic oesophagitis in Denmark have higher use of psychotropic drugs: A Danish nationwide study of psychotropic drug use in 3367 patients and 16,835 matched comparators.
United European Gastroenterol J
June 2024
Background: Eosinophilic oesophagitis (EoE) is a chronic, immune-mediated disease of the oesophagus. Eosinophilic oesophagitis is associated with a substantial disease burden affecting the quality of life and affecting mental health. There are limited data describing the incidence of psychiatric disorders and the use of psychotropic drugs (PDs) in EoE patients.
View Article and Find Full Text PDFBackground: A low incidence of eosinophilic esophagitis (EoE) in children in the North Denmark Region (NDR) were measured in 2007-2017. Few of the children diagnosed before 2017 were treated to remission suggesting a lack of awareness. While there currently are no guidelines for treating EoE in Denmark, a new English guideline was published in 2022 renewing focus on the disease.
View Article and Find Full Text PDFBackground: Food bolus obstruction (FBO) leading to hospital treatment is often associated with eosinophilic oesophagitis (EoE), stenosis, or oesophageal cancer (1). Danish national guidelines recommend that patients with FBO undergo a diagnostic upper endoscopy within two weeks of presentation to exclude possible malignancy, and histological evaluation of eight biopsies (2, 3).
Aims: The aims of this study were to (1) report the incidence and describe the causes and treatment of FBO in the North Denmark Region (NDR), (2) determine the proportion of patients who underwent upper endoscopy and biopsy according to regional and national guidelines, and (3) identify International Classification of Diseases 10th Revision (ICD-10) diagnosis and procedure codes applied to the hospital visits due to FBO in the NDR.