Time-dependent fear memory generalization triggered by phosphodiesterase 5 inhibition during reconsolidation.

Fear generalization, a lack of discrimination between safe and unsafe cues, is a hallmark of posttraumatic stress disorder. The phosphodiesterase 5 (PDE5) regulates the cyclic guanosine monophosphate (cGMP) pathway, which has been proposed to be involved in fear memory generalization. However, whether PDE5 activity underlies fear memory generalization remains unexplored.

Anti-Neuroinflammatory Effects of Prenylated Indole Alkaloids from the Antarctic Fungus sp. Strain SF-7367.

Inflammation has always been considered a trigger or consequence of neurodegenerative diseases, and the inhibition of inflammation in the central nervous system can effectively protect nerve cells. Several studies have indicated that various natural products inhibit neuroinflammation. Among these, Antarctic fungal metabolites have pharmacological activities and a developmental value.

Relationship Between Frequency Domain Indicators of Heart Rate Variability and Both Age and Duration of Illness in Patients with Headache: A Cross-Sectional Study.

: One of the most prevalent neurological conditions in the world, headaches impact a large number of people. Patients who experience headaches often have autonomic nervous system dysfunction, which can influence the onset and duration of headaches. Heart rate variability (HRV) serves as an indicator of the autonomic nervous system's activity and balance.

Aetiology of chronic liver disease is a valuable factor for stratifying adverse outcomes of acute decompensation: prospective observational study.

Background/aims: Acute decompensation (AD) is defined as the development of complications related to portal hypertension and liver dysfunction that affect the progression of chronic liver disease (CLD) or liver cirrhosis (LC). Variations exist in patient demographics and prognostic outcomes of AD based on the aetiology of CLD, encompassing LC. However, limited research has been conducted to analyse these discrepancies across aetiologies.

Full Body-Worn Textile-Integrated Nanomaterials and Soft Electronics for Real-Time Continuous Motion Recognition Using Cloud Computing.

Recognizing human body motions opens possibilities for real-time observation of users' daily activities, revolutionizing continuous human healthcare and rehabilitation. While some wearable sensors show their capabilities in detecting movements, no prior work could detect full-body motions with wireless devices. Here, we introduce a soft electronic textile-integrated system, including nanomaterials and flexible sensors, which enables real-time detection of various full-body movements using the combination of a wireless sensor suit and deep-learning-based cloud computing.