Impact of Metastatic Pattern on Survival Following Pancreatectomy for Cancer.

Background And Methods: The incidence of pancreatic cancer is increasing, and up to 55% of patients present with metastatic disease at the time of diagnosis. Many patients also develop metastatic disease following surgical resection. The impact of metastatic patterns on outcomes has not been described.

A High-Affinity Monoclonal Antibody Against the Pancreatic Ductal Adenocarcinoma Target, Anterior Gradient-2 (AGR2/PDIA17).

Background/objectives: Anterior Gradient-2 (AGR2/PDIA17) is a member of the protein disulfide isomerase (PDI) family of oxidoreductases. AGR2 is up-regulated in several solid tumors, including pancreatic ductal adenocarcinoma (PDAC). Given the dire need for new therapeutic options for PDAC patients, we investigated the expression and function of AGR2 in PDAC and developed a novel series of affinity-matured AGR2-specific single-chain variable fragments (scFvs) and monoclonal antibodies.

Mapping the Impact of Anti-LGBT Legislation on Graduate Surgical Education.

Background: LGBTQ medical students and surgery residents face myriad structural barriers. The American Civil Liberties Union (ACLU) reports 492 pieces of state-level legislation targeting Lesbian, Gay, Bisexual, Transgender, and Queer (LGBTQ) people in the past year. These bills including bans on medical care, "don't say gay" bills, exclusion from anti-discrimination protections, and more.

Aspirin guided by coronary artery calcium scoring for primary cardiovascular prevention in persons with subclinical coronary atherosclerosis.

Although endurance exercise is cardioprotective, episodes of strenuous physical exertion can trigger sudden cardiac death. While marathon training promotes overall heart health, running such races transiently increases cardiac arrest risk, mainly in middle-aged men with subclinical coronary atherosclerosis. Coronary artery calcium scanning has been advised for risk stratification to identify those who benefit from enhanced primary prevention.

Surprising acidity for the methylene of 1,3-indenocorannulenes?

Quantitative assessment of the first acidity constant (p ) for BFC (27.6 in CHCN) and FIC (27.8 in CHCN) shows the methylene protons to be significantly more acidic than those in related cyclopentadiene (32 in CHCN), indene (34 in CHCN), or fluorene (37 in CHCN) and comparable to the methine of 9-perfluorophenylfluorene (28.