Publications by authors named "J H Purohit"
Article Synopsis
- The study examines the clinical utility and economic implications of pharmacogenetic testing (PGT) for warfarin therapy in low to middle-income countries, comparing it to standard care (SOC).
- It involved a randomized trial with 168 patients and found that those receiving PGT-guided therapy spent significantly more time in the therapeutic INR range and reached this range faster than those on SOC.
- Despite the slightly higher lifetime costs for PGT therapy, the quality-adjusted life years (QALY) gained were similar for both treatment strategies, suggesting that cost-effective benefits may exist with PGT in specific scenarios.
Introduction: A recent study has demonstrated that social factors have an impact on the condition of dental implants. The present investigation investigated how varied alcohol intake quantities might alter the condition of dental implants and related peri-implant inflammation.
Materials And Methods: This retrospective research was piloted in a tertiary care center, and implants inserted between 2010 and 2022 were evaluated through a retrospective cohort analysis.
Aim: This study was intended to assess and relate the clinical anesthetic effectiveness of tramadol hydrochloride and lidocaine.
Methodology: A clinical randomized split-mouth study was piloted among 40 patients who were otherwise healthy but needed to have their maxillary first premolars extracted bilaterally for orthodontic reasons were considered in the research. In each subject on one side (quadrant) of the arch 1.
The N-terminus of Histone H3 is proteolytically processed in aged chicken liver. A histone H3 N-terminus specific endopeptidase (named H3ase) has been purified from the nuclear extract of aged chicken liver. By sequencing and a series of biochemical methods including the demonstration of H3ase activity in bacterially expressed GDH, it was established that the H3ase activity was a moonlighting protease activity of glutamate dehydrogenase (GDH).
View Article and Find Full Text PDFThe nuclear events of a eukaryotic cell, such as replication, transcription, recombination and repair etc. require the transition of the compactly arranged chromatin into an uncompacted state and vice-versa. This is mediated by post-translational modification of the histones, exchange of histone variants and ATP-dependent chromatin remodeling.
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