Perfluoroalkyl chemical adsorption by granular activated carbon: Assessment of particle size impact on equilibrium parameters and associated rapid small-scale column test scaling assumptions.

Single-solute batch kinetic and isotherm experiments were conducted in Type 1 (18.2 MΩ·cm resistivity) water supplemented with 10 mM carbonate buffer (pH 7.75, 25 °C) for nine drinking water relevant perfluoroalkyl chemicals and three bituminous-coal based granular activated carbons (GACs).

Microelectrode investigation of iron and copper surfaces aged in presence of monochloramine.

Ductile iron and copper coupons were aged 137-189 days and 2 days, respectively, with 2 mg Cl L monochloramine under four water chemistries (pH 7 or 9 and 0 or 3 mg L orthophosphate). Subsequently, microelectrode profiles of monochloramine concentration, oxygen concentration, and pH were measured from the bulk water to near the coupon reactive surface, allowing estimation of flux and apparent surface reaction rate constants for monochloramine and oxygen. Both metals showed similar trends with orthophosphate where orthophosphate decreased metal reactivity with monochloramine (pH 9) and oxygen (pH 7).

Evaluation of distribution system water quality during a free chlorine conversion.

Chloraminated drinking water systems commonly use free chlorine conversions (FCCs) to prevent or control nitrification, but unintended water quality changes may occur, including increased disinfection by-product and metal concentrations. This study evaluated water quality in a chloraminated drinking water system and residential locations before, during, and after their annual, planned FCC. Water quality alternated between relatively consistent and variable periods when switching disinfectants.

hiPSC-CM electrophysiology: impact of temporal changes and study parameters on experimental reproducibility.

Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are frequently used for preclinical cardiotoxicity testing and remain an important tool for confirming model-based predictions of drug effects in accordance with the comprehensive in vitro proarrhythmia assay (CiPA). Despite the considerable benefits hiPSC-CMs provide, concerns surrounding experimental reproducibility have emerged. We investigated the effects of temporal changes and experimental parameters on hiPSC-CM electrophysiology.