Publications by authors named "J H Oury"
Article Synopsis
- Muscle-specific kinase (MuSK) is crucial for creating and maintaining neuromuscular synapses, and its activation can help treat diseases affecting these connections, such as congenital myasthenia (CM).
- ARGX-119 is a novel humanized monoclonal antibody designed to specifically activate MuSK, improving neuromuscular junction function without disrupting the natural ligand, neural Agrin.
- In studies, ARGX-119 successfully improved neuromuscular function in mouse models of CM, showing promise for treating related neuromuscular disorders in humans, justifying its further clinical development.
Agonist antibody to MuSK protects mice from MuSK myasthenia gravis.
Proc Natl Acad Sci U S A
September 2024
Article Synopsis
- Myasthenia gravis (MG) is a severe illness that causes muscle weakness because signals from nerves to muscles don't work well.
- In some types of MG, the body's immune system mistakenly attacks important proteins that help muscles respond to signals.
- Researchers found that special antibodies from MG patients can cause muscle disease in mice, but a new type of antibody can help treat it without shutting down the whole immune system.
Needle decompression is a mainstay intervention for tension pneumothorax in trauma medicine. It is used in combat and prehospital medicine when definitive measures are often not available or ideal. It can temporarily relieve increased intrathoracic pressure and treat a collapsed lung or great vessel obstruction.
View Article and Find Full Text PDFA coordinated and complex interplay of signals between motor neurons, skeletal muscle cells, and Schwann cells controls the formation and maintenance of neuromuscular synapses. Deficits in the signaling pathway for building synapses, caused by mutations in critical genes or autoantibodies against key proteins, are responsible for several neuromuscular diseases, which cause muscle weakness and fatigue. Here, we describe the role that four key genes, , , , and , play in this signaling pathway, how an understanding of their mechanisms of action has led to an understanding of several neuromuscular diseases, and how this knowledge has contributed to emerging therapies for treating neuromuscular diseases.
View Article and Find Full Text PDFArticle Synopsis
- This study compares two surgical methods, Hartmann's procedure (HP) and resection with primary anastomosis (RPA), for treating acute left-sided colonic emergencies among 1215 patients from 204 centers globally.
- Results showed that while HP was the more common treatment (57.3%), RPA was favored for younger patients with fewer health issues and those needing surgery sooner.
- The study concluded that although HP is still widely used, RPA might be the better option, emphasizing the importance of patient characteristics and surgeon experience in determining treatment choice.