Publications by authors named "J H Naish"
Background: Heart failure (HF) most commonly occurs in patients who have had a myocardial infarction (MI), but factors other than MI size may be deterministic. Fibrosis of myocardium remote from the MI is associated with adverse remodeling. We aimed to 1) investigate the association between remote myocardial fibrosis, measured using cardiovascular magnetic resonance (CMR) extracellular volume fraction (ECV), and HF and death following MI, 2) identify predictors of remote myocardial fibrosis in patients with evidence of MI and determine the relationship with infarct size.
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- Oxygen-Enhanced Magnetic Resonance Imaging (OE-MRI) can effectively map the oxygenation levels in the placenta, offering a new way to assess placental health in pregnant women.
- In a study with twelve healthy pregnant subjects, both 2D and 3D imaging techniques were compared, revealing that 3D OE-MRI successfully covered the entire placenta without significant differences in average relaxation rates from the 2D scans.
- While baseline measurements showed slight variances, no linkage was found between relaxation rates and gestational age, suggesting that the technique can detect detailed placental oxygenation changes during healthy pregnancies.
Article Synopsis
- * Magnetic resonance imaging (MRI) has emerged as a valuable tool for assessing both structural and functional lung issues without radiation, particularly beneficial for early detection in smokers and COPD patients.
- * These imaging techniques allow for comprehensive evaluations of lung structure and function, helping to better understand disease patterns and guide treatment decisions.
Purpose: To demonstrate proof-of-concept of a T *-sensitized oxygen-enhanced MRI (OE-MRI) method at 3T by assessing signal characteristics, repeatability, and reproducibility of dynamic lung OE-MRI metrics in healthy volunteers.
Methods: We performed sequence-specific simulations for protocol optimisation and acquired free-breathing OE-MRI data from 16 healthy subjects using a dual-echo RF-spoiled gradient echo approach at 3T across two institutions. Non-linear registration and tissue density correction were applied.
Purpose: Dynamic lung oxygen-enhanced MRI (OE-MRI) is challenging due to the presence of confounding signals and poor signal-to-noise ratio, particularly at 3 T. We have created a robust pipeline utilizing independent component analysis (ICA) to automatically extract the oxygen-induced signal change from confounding factors to improve the accuracy and sensitivity of lung OE-MRI.
Methods: Dynamic OE-MRI was performed on healthy participants using a dual-echo multi-slice spoiled gradient echo sequence at 3 T and cyclical gas delivery.