Fear conditioning modulates the intrinsic excitability of ventral hippocampal CA1 neurons in male rats.

The hippocampus has a known role in learning and memory, with the ventral subregion supporting many learning tasks involving affective responding, including fear conditioning. Altered neuronal intrinsic excitability reflects experience-dependent plasticity that supports learning-related behavioral changes. Such changes have previously been observed in the dorsal hippocampus following fear conditioning, but little work has examined the effect of fear conditioning on ventral hippocampal intrinsic plasticity.

A juvenile spinner shark in southern New England: A rare visitor or a sign of change?

A juvenile spinner shark, Carcharhinus brevipinna, was captured and released in the coastal waters of Rhode Island, USA, where range delineations based on historic records of spinner sharks and the species' congener, the blacktip shark, Carcharhinus limbatus, are plagued by misidentification. The shark in question was within the size range of neonates for C. brevipinna and bore a partially healed umbilical wound.

Extracorporeal membrane oxygenation in trauma patient in France: A retrospective nationwide registry.

Background: Indications for Veno-venous (VV) or veno-arterial (VA) extracorporeal membrane oxygenation (ECMO) after trauma rely on poor evidence. The main aims were to describe the population of trauma patients requiring either VV or VA ECMO and report their clinical management and outcomes.

Methods: An observational multicentre retrospective study was conducted in 17 Level 1 trauma centres in France between January 2010 and December 2021.

Increased translation driven by non-canonical EZH2 creates a synthetic vulnerability in enzalutamide-resistant prostate cancer.

Overcoming resistance to therapy is a major challenge in castration-resistant prostate cancer (CRPC). Lineage plasticity towards a neuroendocrine phenotype enables CRPC to adapt and survive targeted therapies. However, the molecular mechanisms of epigenetic reprogramming during this process are still poorly understood.