Publications by authors named "J H Megens"
Background: A preliminary national audit of real fasting times including 3324 children showed that the fasting times for clear fluids and light meals were frequently shorter than recommended in current guidelines, but the sample size was too small for subgroup analyses.
Aims: Therefore, the primary aim of this extended study with more participating centers and a larger sample size was to determine whether shortened fasting times for clear fluids or light meals have an impact on the incidence of regurgitation or pulmonary aspiration during general anesthesia in children. The secondary aim was to evaluate the impact of age, emergent status, ASA classification, induction method, airway management or surgical procedure.
Background: Mucopolysaccharidoses (MPS) are hereditary storage diseases; airway management typically worsens in these patients with the progression of the disease.
Objective(s): To assess the incidence of perioperative complications in children with MPS and the impact of enzyme replacement therapy (ERT) followed by hematopoietic stem cell transplantation (HSCT).
Methods: The records of patients with MPS treated with ERT followed by HSCT, who received anesthesia at the Wilhelmina Children's Hospital between 2003 and 2012, were reviewed.
Article Synopsis
- * Retrospective analysis involved 44 pediatric patients, revealing an average blood loss of 55 ml per kg, with many receiving red blood cells (average of 38 ml per kg) and fresh frozen plasma (average of 28 ml per kg). Longer surgery times and lower patient body weight were linked to increased bleeding and transfusions.
- * The findings suggest high rates of blood loss and transfusions during craniosynostotic corrections and propose potential solutions, such as forming specialized medical teams, adopting minimally invasive techniques, and optimizing anesthesia to reduce the need
Objective: Adverse effects of long-term cross-sex hormone administration to transsexuals are not well documented. We assessed mortality rates in transsexual subjects receiving long-term cross-sex hormones.
Design: A cohort study with a median follow-up of 18.
Background: Until recently, individual doctors and nurses in our pediatric hospital made decisions about the application of pain relief in patients, resulting in a wide variety of practice. The main task of our pain group was to develop hospital-wide practice standards for acute pain management to improve care. One of the key points of the pain policy was the introduction of pain assessment tools (COMFORT and Visual Analogue Scale).
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