Publications by authors named "J H Los"
Article Synopsis
- * Patients in the trial receive either evolocumab or a placebo for 12 weeks, alongside high-intensity statin therapy, and are monitored for changes in plaque size and composition using advanced imaging techniques.
- * This study is notable for being the first to assess how significant reductions in low-density lipoprotein cholesterol (LDL-C) could impact the health of non-critical coronary lesions shortly after treatment.
Article Synopsis
- Two-photon microscopy (2PM) is a key technique in biology for examining intact tissues, but imaging depth is usually restricted to 600-800 μm due to scattering in adult mammalian tissues like mouse brains.
- * Researchers aimed to enhance imaging depth by utilizing shortwave near-infrared (SWIR) light, which has faced challenges due to the lack of suitable detectors and probes.
- * This study introduces a new array of superconducting nanowire single-photon detectors (SNSPDs) that, combined with specific fluorescent dyes, enables imaging depths greater than 1.1 mm in mouse brains, representing a significant advancement in deep tissue imaging technology.
Introduction: Patients with acute coronary syndrome (ACS) have high event rates related to non-culprit (NC) lesions, therefore plaque composition of these lesions is of great interest. Although marginal atherosclerotic lesions were studied extensively, more significant lesions might have more high-risk characteristics.
Aim: To compare differences in high-risk lesion characteristics between significant versus non-stenotic NC plaques in ACS and the discrepancies with chronic coronary syndrome (CCS) patients.
Association Between Coronary Artery Spasm and Atherosclerotic Disease.
JACC Cardiovasc Imaging
July 2024
In at least one-half of the patients with angina or ischemia and nonobstructive coronary arteries undergoing coronary function testing, coronary artery spasm (CAS) is detected. CAS is associated with an adverse prognosis regarding recurrent complaints and ischemic events. Current treatment options are mainly focused on the complaints, not on the underlying pathophysiological process.
View Article and Find Full Text PDFThe dynamic heterogeneities occurring just before the transition to the glassy phase have been named as the cause of amorphization in supercooled systems. Numerous studies conducted so far have confirmed this hypothesis, and based on it, a widely accepted solution to the puzzle of glass transition has been developed. This report focuses on verifying the existence of a strong pretransitional anomaly near the glass transition Tg.
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