Publications by authors named "J H Lipschutz"
Article Synopsis
- Melanoma is a type of cancer that originates in melanocytes, mainly found in the skin, but can also arise in other areas like the eye or mucous membranes.
- While new therapies are improving treatment for metastatic melanoma, challenges like resistance to these treatments remain significant.
- A case study of a male patient highlights the complexities of melanoma, emphasizing the need for better management strategies and understanding of the disease for improved patient outcomes.
SARS-CoV-2 can induce a hypercoagulable state, occasionally resulting in pulmonary venous thrombosis (PVT) due to inflammation and endothelial injury. Documented cases of PVT with active COVID-19 and post-COVID are rare. We report a 40-year-old postpartum female with unprovoked PVT following a recent nonhospitalized COVID-19 infection.
View Article and Find Full Text PDFParoxysmal nocturnal hemoglobinuria (PNH) is an uncommon genetic disorder that affects red blood cell production, causing symptoms like fatigue, abdominal pain, and shortness of breath. This condition can also result in dark urine and an increased risk of infections. Diagnosis of PNH involves genetic testing and flow cytometry, which can confirm the presence of the condition.
View Article and Find Full Text PDFMesangial cells offer structural support to the glomerular tuft and regulate glomerular capillary flow through their contractile capabilities. These cells undergo phenotypic changes, such as proliferation and mesangial expansion, resulting in abnormal glomerular tuft formation and reduced capillary loops. Such adaptation to the changing environment is commonly associated with various glomerular diseases, including diabetic nephropathy and glomerulonephritis.
View Article and Find Full Text PDFArticle Synopsis
- The exocyst and a protein called Ift88 are important for making tiny structures called cilia, which help cells recover from injury.
- When Exoc5 is increased, it helps cells grow longer cilia and recover better from damage, while reducing its amount leads to problems in cells and higher levels of harmful substances.
- Mice lacking cilia showed more damage to their kidneys, highlighting how weak cilia and bad mitochondria (powerhouses of the cell) can make kidney injuries worse and disrupt a substance called tryptophan, pointing to possible new treatments.