Publications by authors named "J H LaBianca"
Article Synopsis
- Autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) often occur together and have genetic components influencing their risk.
- In a study of 39 families, researchers found that known genetic variants explained about 10% of the variance in comorbid ASD/ADHD, with lower contributions for ASD (4%) and ADHD (2%) individually.
- The study indicates that individuals with adult ASD/ADHD needing ongoing specialist care carry a higher burden of rare genetic variants compared to unaffected family members, while affected relatives show intermediate levels.
Brief Report: Clusters and Trajectories Across the Autism and/or ADHD Spectrum.
J Autism Dev Disord
October 2018
Autism Spectrum Disorder (ASD) and Attention Deficit Hyperactivity Disorder (ADHD) frequently co-occur and show high genetic correlation. With the introduction of DSM-5, there is a new concept of an ASD and/or ADHD spectrum (ASD/ADHD). This study aimed to identify predictors of severity and need of healthcare within this spectrum.
View Article and Find Full Text PDFThe number of children and adolescents with psychiatric disorders being treated with antipsychotic medication is increasing significantly; however, only a limited evidence-base is available on this topic, especially when children are concerned. This study reports and discusses the use of antipsychotic medication in children and adolescents below 19 years of age in Denmark. A national cross-sectional survey registered the use of antipsychotic drugs on a given date.
View Article and Find Full Text PDFStructural brain abnormalities in early onset first-episode psychosis.
J Neural Transm (Vienna)
October 2007
Background: Brain morphometry in children and adolescents with first-episode psychosis offer a unique opportunity for pathogenetic investigations.
Methods: We compared high-resolution 3D T1-weighted magnetic resonance images of the brain in 29 patients (schizophrenia, schizotypal disorder, delusional disorder or other non-organic psychosis), aged 10-18 to those of 29 matched controls, using optimized voxel-based morphometry.
Results: Psychotic patients had frontal white matter abnormalities, but expected (regional) gray matter reductions were not observed.
A 27-year-old man positive for human immunodeficiency virus (HIV) presented with severe depressive stupor, peripheral neuropathy, and myelopathy. The onset of psychiatric symptoms, closely followed by neurological symptoms, without other possible somatic etiology suggests that HIV itself might precipitate psychosis. The patient was treated successfully with electroconvulsive therapy.
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