Publications by authors named "J H Kocsis"
Spinal cord injury (SCI) disrupts the blood-spinal cord barrier (BSCB) exacerbating damage by allowing harmful substances and immune cells to infiltrate spinal neural tissues from the vasculature. This leads to inflammation, oxidative stress, and impaired axonal regeneration. The BSCB, essential for maintaining spinal cord homeostasis, is structurally similar to the blood-brain barrier.
View Article and Find Full Text PDFUrinary incontinence (UI) is a prevalent condition that significantly impacts the quality of life. This study aimed to validate the Hungarian version of the International Consultation on Incontinence Questionnaire-Female Lower Urinary Tract Symptoms (ICIQ-FLUTS) and assess its psychometric properties in the context of the Hungarian population. A cross-sectional study involved 215 Hungarian-speaking women with a mean age of 67.
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- * Seven patients received autologous MSCs without any serious side effects, showing no tumors or neurological decline throughout the process.
- * Notable functional improvements and enhanced quality of life were reported 90 and 180 days after the infusion, indicating that this treatment could be beneficial for chronic SCI, though further large-scale studies are required for conclusive results.
Article Synopsis
- Recent trials showed limited recovery from stroke with a single MSC infusion, but animal studies suggest multiple infusions could improve outcomes by promoting neural plasticity.
- This study tested various MSC infusion regimes in rats after inducing a stroke to assess their impact on functional recovery and brain structure.
- Results indicated that multiple MSC infusions significantly enhanced motor recovery and increased the thickness and area of the corpus callosum, correlating with improved behavioral outcomes.
The impact of childhood abuse on the presentation of bipolar disorder could be further elucidated by comparing the networks of affective symptoms among individuals with and with no history of childhood abuse. Data from 476 participants in the Clinical Health Outcomes Initiative in Comparative Effectiveness for Bipolar Disorder study were used to fit several regularised Gaussian Graphical Models. Differences in the presentation of depressive and manic symptoms were uncovered: only among participants with a history of childhood abuse, inadequacy and pessimism were central symptoms in the network of depressive symptoms, while racing thoughts was an important symptom in the network of manic symptoms.
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