Publications by authors named "J H Klingler"
Background: Hemangioblastomas are highly vascularized tumors that may be associated with extensive architecture of the surrounding pathological vessels. The distinction between feeding arteries and draining veins is usually not obvious during microsurgical en-bloc tumor resection. The aim of this investigation is to provide recommendations in which hemangioblastomas intraoperative indocyanine green (ICG) videoangiography might be beneficial for safe en-bloc tumor resection.
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- The study investigates a new minimally invasive technique for placing cervical pedicle screws and rods through small skin incisions, aiming to reduce complications and pain while promoting faster recovery in patients with cervical instability.
- The retrospective analysis included six male patients treated between August 2022 and August 2023, focusing on screw placement accuracy and monitoring for complications.
- Results showed 84.4% of screws were positioned excellently, with no significant neurological issues or revision surgeries, although one patient died from a non-surgical related pulmonary embolism.
To evaluate the efficacy and safety of minimally invasive tubular removal of spinal schwannoma and neurofibroma. In this single-centre study, we retrospectively analysed 49 consecutive patients who underwent minimally invasive removal of a total of 51 benign spinal nerve sheath tumors using a non-expandable (n = 18) or expandable tubular retractor (n = 33) retractor system between June 2007 and December 2019. The extent of resection, surgical complications, neurological outcome, operative time, and estimated blood loss were recorded.
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- Optic nerve and chiasm hemangioblastomas are rare tumors, often seen in patients with von Hippel-Lindau (VHL) disease, and have limited documentation in clinical literature.
- A study analyzed 12 VHL patients with these tumors, gathering clinical data and MRI results to establish treatment strategies.
- Findings suggest most tumors are slow-growing and asymptomatic, but some patients may experience rapid progression, highlighting the importance of monitoring and individualized treatment approaches.
Introduction: Antibodies against the SARS-CoV-2 spike protein are a critical immune determinant for protection against the virus. While virus neutralization is a key function of spike-specific antibodies, antibodies also mediate Fc-dependent activities that can play a role in protection or pathogenesis.
Methods: This study characterized serum antibody responses elicited after two doses of heterologous adenovirus-vectored (Ad26/ Ad5) vaccines.