Publications by authors named "J H Jacoby"
Design and commissioning of the PRIOR-II "proton microscope for FAIR".
Rev Sci Instrum
December 2024
A new high energy proton radiography facility PRIOR-II (Proton Microscope for FAIR) has been designed, constructed, and successfully commissioned at the GSI Helmholtzzentrum für Schwerionenforschung (Darmstadt, Germany) pushing the technical boundaries of charged particle radiography with normal conducting magnets to the limits. The setup is foreseen to become a new and powerful user facility for carrying out fundamental science experiments in the fields of plasma and shock wave physics, material science, and medical physics. It will help address several unsolved scientific challenges, which require high-speed and precise non-invasive diagnostic methods capable of probing matter with up to 100 g/cm2 areal density.
View Article and Find Full Text PDFHypothetical axions provide a compelling explanation for dark matter and could be emitted from the hot solar interior. The CERN Axion Solar Telescope has been searching for solar axions via their back conversion to x-ray photons in a 9-T 10-m long magnet directed toward the Sun. We report on an extended run with the International Axion Observatory pathfinder detector, doubling the previous exposure time.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to compare two MRI techniques: conventional T1-weighted VIBE and a high-resolution (HR-VIBE) version, focusing on image quality and lesion detection in upper abdominal imaging.
- Conducted at a tertiary center between December 2023 and March 2024, 50 patients underwent both MRI sequences, and various aspects of the images were evaluated by three blinded readers.
- Results revealed that HR-VIBE provided better image clarity and detection rates for lesions (97.5% vs. 93.2%) while maintaining a similar acquisition time, highlighting its potential advantages over the conventional method.
Context: The Bigfoot Unity Diabetes Management System integrates Abbott FreeStyle Libre 2 continuous glucose monitoring (CGM) data into a smart pen cap and mobile app enabling clinician-directed insulin dose recommendations and real-time alerts.
Objective: The objective was to analyze real world 6-month glycemic control in a prospective study for individuals using the System for multiple daily insulin injections (MDI).
Methods: We conducted a 6-month analysis from the BURST study (NCT05088265) of individuals with type 1 or type 2 diabetes (T2D).
Article Synopsis
- Drug-induced long QT syndrome (diLQTS) is a serious side effect of over 150 medications that can lead to dangerous heart conditions; the study aimed to validate a genetic risk score for predicting this syndrome.
- Researchers analyzed data from a large cohort of patients taking high-risk QT-prolonging drugs and found that the risk score was significantly associated with diLQTS in White patients, indicating a higher likelihood of QT prolongation during treatment.
- Although the risk score showed promise in identifying high-risk individuals, the study was underpowered to confirm its effectiveness across African American and Asian populations, highlighting the need for larger sample sizes in diverse groups.