Design, synthesis and cholinesterase inhibitory properties of new oxazole benzylamine derivatives.

The enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are primary targets in attenuating the symptoms of neurodegenerative diseases. Their inhibition results in elevated concentrations of the neurotransmitter acetylcholine which supports communication among nerve cells. It was previously shown for 4/5-arylethenyloxazole compounds to have moderate AChE and BChE inhibitory properties.

Episodic Visual Snow Associated With Migraine Attacks.

This case series describes 3 individuals with episodic visual snow, co-occurring with migraines.

A Hole Delocalization Strategy: Photoinduced Mixed-Valence MLCT States Featuring Extended Lifetimes.

Bimetallic -[Ru(tpm)(bpy)(μNC)Ru(L)(CN)], where bpy is 2,2'-bipyridine, tpm is tris(1-pyrazolyl)methane and L = 4-methoxypyridine (MeOpy) or pyridine (py), was examined using ultrafast vis-NIR transient absorption spectroscopy. Of great relevance are the longest-lived excited states in the form of strongly coupled photoinduced mixed-valence systems, which exhibit intense photoinduced absorptions in the NIR and are freely tunable by the judicious choice of the coordination spheres of the metallic ions. Using the latter strategy, we succeeded in tailoring the excited state lifetimes of bimetallic complexes and, in turn, achieving significantly longer values relative to related monometallic complexes.

Electronic Energy Transduction from {Ru(py)} Chromophores to Cr(III) Luminophores.

Despite the large body of work on {Ru(bpy)} sensitizer fragments, the same attention has not been devoted to their {Ru(py)} analogues. In this context, we explored the donor-acceptor trans-[Ru(L){(μ-NC)Cr(CN)}], where L = pyridine, 4-methoxypyridine, 4-dimethylaminopyridine. We report on the synthesis and the crystal structure as well as the electrochemical, spectroscopical, and photophysical properties of these trimetallic complexes, including transient absorption measurements.

Counterion effects on the ultrafast dynamics of charge-transfer-to-solvent electrons.

We performed femtosecond transient absorption (TA) experiments to monitor the solvation dynamics of charge-transfer-to-solvent (CTTS) electrons originating from UV photoexcitation of ammoniated iodide in close proximity to the counterions. Solutions of KI were prepared in liquid ammonia and TA experiments were carried out at different temperatures and densities, along the liquid-gas coexistence curve of the fluid. The results complement previous femtosecond TA work by P.