Publications by authors named "J H Heijmans"
Objectives: Accuracy of diagnostic tests for invasive pulmonary aspergillosis (IPA) using bronchoalveolar lavage fluid (BALF) remains suboptimal. Elevated tissue iron in lung transplant and murine models is linked to invasive Aspergillus growth. This study examines the correlation between BALF iron levels, IPA, and 12-week mortality.
View Article and Find Full Text PDFBackground: Relapsed acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (HR-MDS) are associated with a poor prognosis. It is unknown which re-induction therapy provides the highest chance of durable remission. Commonly used therapies are high dose cytarabine (HiDAC) and triple therapy consisting of fludarabine, cytarabine, and idarubicin combined with granulocyte colony-stimulating factor (FLAG-IDA).
View Article and Find Full Text PDFArticle Synopsis
- Chronic airway inflammation can lead to conditions like COPD and asthma, causing issues such as goblet cell hyperplasia and obstructed airflow in chronic bronchitis.
- Traditional animal testing methods are being replaced by in vitro three-dimensional cultures, but these often miss important characteristics of the human airway structure.
- The Bronchus-on-a-Chip (BoC) system was developed to create a more accurate model of bronchial epithelium, successfully mimicking human responses to inflammation and improving the testing of chronic airway conditions.