Publications by authors named "J H H van Eck"
Protection against (EPS) challenge seems to be genotype-serotype-specific.Genotype B (O78:H4) gave (almost) full protection against genotypes B, F and H (all O78:H4).Genotype D (O11:H12) incited partial protection.
View Article and Find Full Text PDFMotivation: Hydrophobic patches on protein surfaces play important functional roles in protein-protein and protein-ligand interactions. Large hydrophobic surfaces are also involved in the progression of aggregation diseases. Predicting exposed hydrophobic patches from a protein sequence has shown to be a difficult task.
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- Pathogenic missense variants in the synaptic vesicle protein synaptotagmin-1 (SYT1) lead to a neurodevelopmental disorder with motor delays, intellectual disabilities, and visual impairments due to impaired neurotransmitter release.
- Research on cultured neurons has shown that specific variants in the SYT1 protein hinder exocytosis, causing varying degrees of dysfunction based on the variant's location.
- The study establishes a direct correlation between the exocytic efficiency of SYT1 variants and the severity of developmental impairments, indicating a clear relationship between genetic mutations, neurotransmitter release, and functional outcomes, paving the way for potential therapeutic approaches.
The impact of the emerging tick-borne pathogen Borrelia miyamotoi is not fully understood. We utilised a protein array to investigate B. miyamotoi seroreactivity in various human populations in the Netherlands and Sweden.
View Article and Find Full Text PDFOnline self-evaluation of fMRI-based neurofeedback performance.
Philos Trans R Soc Lond B Biol Sci
December 2024
This study explores the subjective evaluation of supplementary motor area (SMA) regulation performance in a real-time functional magnetic resonance imaging neurofeedback (fMRI-NF) task. In fMRI-NF, people learn how to self-regulate their brain activity by performing mental actions to achieve a certain target level (TL) of blood-oxygen-level-dependent (BOLD) activation. Here, we studied two types of self-evaluation: performance predictions and perceived confidence in the prediction judgement.
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