Colocalization of hedgehog arterivirus 1 (HhAV-1) and histologic lesions in the European hedgehog () with neurological disease.

The European hedgehog () is a protected species of conservation concern in the UK. In recent years, there have been multiple incidents of fatal encephalitis in captive hedgehogs in wildlife rescue centers associated with the molecular detection of a hedgehog arterivirus (HhAV-1). However, it remains unclear whether the virus is the causative agent of the central nervous system (CNS) lesions.

InterPro: the protein sequence classification resource in 2025.

InterPro (https://www.ebi.ac.

Effect of supramolecular peptide hydrogel scaffold charge on HepG2 viability and spheroid formation.

Supramolecular bioinspired self-assembling peptide hydrogel (SAPH) scaffolds represent a class of fully defined synthetic materials whose chemical and mechanical properties can be finely engineered. In this study, the relationship between SAPHs physicochemical properties and HepG2 cells viability, spheroid formation and function are discussed. We first report that negatively charged SAPHs promote hepatocyte proliferation and spheroids formation 3D culture while positively charged SAPHs lead to hepatocyte death irrespective of the hydrogel mechanical properties.

RGD-functionalised self-assembling peptide hydrogel induces a proliferative profile in human osteoblasts in vitro.

Self-assembling peptide hydrogels (SAPHs) have been used in the past decade as reliable three-dimensional (3D) synthetic scaffolds for the culture of a variety of mammalian cells in vitro. Thanks to their versatile physicochemical properties, they allow researchers to tailor the hydrogel properties, including stiffness and functionality to the targeted cells and cells' behaviour. One of the advantages of using SAPH scaffolds is the ease of functionalisation.