Androgen receptor drives polyamine synthesis creating a vulnerability for prostate cancer.

Supraphysiological androgen (SPA) treatment can paradoxically restrict growth of castration-resistant prostate cancer with high androgen receptor (AR) activity, which is the basis for use of Bipolar Androgen Therapy (BAT) for patients with this disease. While androgens are widely appreciated to enhance anabolic metabolism, how SPA-mediated metabolic changes alter prostate cancer progression and therapy response is unknown. Here, we report that SPA markedly increased intracellular and secreted polyamines in prostate cancer models.

HIF-2α drives T2 cells.

Inhibiting HIF-2α impairs the development and function of asthma-promoting helper T cells in mice.

On the Broader Significance of Maternal Sensitivity: Mothers' Early and Later Sensitive Parenting Matter to Children's Language, Executive Function, Academics, and Self-Reliance.

Researchers have demonstrated the important contribution of mothers' sensitive parenting to children's developing cognition over the first 5 years of life, yet studies examining sensitivity beyond the early years, controlling for earlier effects, are limited. In this exploratory study, we examined the developmental pathways through which mothers' early and later sensitive parenting transacted with children's language, executive function, academics, and self-reliance to predict child outcomes from infancy to adolescence. To a national longitudinal dataset (n = 1364; 52% male; 80% white), we applied random intercept cross-lagged panel modeling to examine between-person and within-person associations for maternal sensitivity and child outcomes.