Publications by authors named "J H Erlich"
Article Synopsis
- Heart failure is prevalent among hemodialysis patients, and high flow arteriovenous fistulas (AVFs) may be a risk factor; this study aims to create a predictive model to identify patients at risk of developing high flow AVFs.
- Using data from 366 patients, the study compared various machine learning models to predict high flow AVF development, finding that the bootstrap forest model was the most effective.
- Results showed that while 31.4% of patients had high flow AVFs, and 24.9% developed heart failure after AVF creation, no direct correlation was found between AVF flow and the onset of heart failure or death post-creation.
The neural mechanisms of motor planning have been extensively studied in rodents. Preparatory activity in the frontal cortex predicts upcoming choice, but limitations of typical tasks have made it challenging to determine whether the spatial information is in a self-centered direction reference frame or a world-centered position reference frame. Here, we trained male rats to make delayed visually guided orienting movements to six different directions, with four different target positions for each direction, which allowed us to disentangle direction versus position tuning in neural activity.
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- Asthma exacerbations are frequently treated in pediatric emergency departments, requiring timely administration of oral corticosteroids and bronchodilators to improve patient outcomes.
- A quality improvement initiative aimed to cut the time from patient arrival to the administration of dexamethasone (a corticosteroid) in children with severe asthma from 60 to 30 minutes, using collaborative strategies among healthcare staff.
- The effort successfully reduced the average time to dexamethasone administration from 59 to 38 minutes, although the length of stay in the emergency department increased for discharged patients, with no change in hospital admission rates.
Influenza A virus (IAV) infection in pregnancy resembles a preeclamptic phenotype characterised by vascular dysfunction and foetal growth retardation. Given that low dose aspirin (ASA) is safe in pregnancy and is used to prevent preeclampsia, we investigated whether ASA or NO-conjugated aspirin, NCX4016, resolve vascular inflammation and function to improve offspring outcomes following IAV infection in pregnant mice. Pregnant mice were intranasally infected with a mouse adapted IAV strain (Hkx31; 10 plaque forming units) and received daily treatments with either 200µg/kg ASA or NCX4016 via oral gavage.
View Article and Find Full Text PDFProstate cancer is ranked second in the world for cancer-related deaths in men, highlighting the lack of effective therapies for advanced-stage disease. Toll-like receptors (TLRs) and immunity have a direct role in prostate cancer pathogenesis, but TLR9 has been reported to contribute to both the progression and inhibition of prostate tumorigenesis. To further understand this apparent disparity, we have investigated the effect of TLR9 stimulation on prostate cancer progression in an immune-competent, syngeneic orthotopic mouse model of prostate cancer.
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