Glucagon-like peptide-1 agonist safety and efficacy in a multiple sclerosis cohort.

Background: While glucagon-like peptide-1 agonist medications (GLP-1s) are on the rise, their safety and efficacy have not been studied in people with MS (PwMS).

Objective: To investigate any adverse effects of GLP-1 medications in the MS population as well as their effectiveness for weight loss and vitamin D augmentation.

Methods: We retrospectively identified PwMS who utilized a GLP-1 medication from 2006 to 2024.

Circumventing Kinetic Barriers to Metal Hydride Formation with Metal-Ligand Cooperativity.

We report the two-electron, one-proton mechanism of cobalt hydride formation for the conversion of [CoCp(PN)(CHCN)] to [HCoCp(PN)]. This complex catalytically converts CO to formate under CO reduction conditions, with hydride formation as a key elementary step. Through a combination of electrochemical measurements, digital simulations, theoretical calculations, and additional mechanistic and thermochemical studies, we outline the explicit role of the PN ligand in the proton-coupled electron transfer (PCET) reactivity that leads to hydride formation.

Atypical disseminated herpes zoster infections in patients with demyelinating disease treated with dimethyl fumarate.

We report two patients who developed atypical, disseminated herpes zoster infections while on dimethyl fumarate (DMF) treatment, one with varicella zoster virus (VZV) encephalitis and another with herpes zoster oticus resulting in lasting motor and sensory deficits. We recommend vaccination against VZV prior to DMF initiation be incorporated as standard of care, as ensuring patients are protected against VZV before starting DMF can prevent such severe outcomes.