Publications by authors named "J H Crowe"

Objective: To assess the utility of a bespoke smartphone app to map noise and vibration exposure across neonatal road ambulance journeys.

Design And Setting: Prospective observational study of ambulance journeys across a large UK neonatal transport service. Smartphones, with an in-house developed app, were secured to incubator trolleys to collect vibration and noise data for comparison with international standards.

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Objective: To identify risk factors for clinically-important drowning-associated lung injury (ciDALI) in children.

Study Design: This was a cross-sectional study of children (0 through18 years) who presented to 32 pediatric emergency departments (EDs) from 2010 through 2017. We reviewed demographics, comorbidities, prehospital data, chest radiographs reports, and ED course from emergency medical services, medical, and fatality records.

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Background: Chronic lymphocytic leukaemia (CLL) typically presents with asymptomatic, early-stage disease that is monitored until disease progression ('treatment-naïve' CLL). The objective of this pilot study was to assess the feasibility and preliminary safety of an exercise program in treatment-naïve CLL. We also sought to preliminarily assess the impact of the exercise program on disease activity, as it has been proposed that exercise training may reduce disease outgrowth in treatment-naïve CLL.

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Development of an efficacious universal influenza vaccines remains a long-sought goal. Current vaccines have shortfalls such as mid/low efficacy and needing yearly strain revisions to account for viral drift/shift. Horses undergo bi-annual vaccines for the H3N8 equine influenza virus, and surveillance of sera from vaccinees demonstrated very broad reactivity and neutralization to many influenza strains.

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Article Synopsis
  • Between 2013 and 2016, the effectiveness of the A/H1N1pdm09 component in the live attenuated influenza vaccine (LAIV) was lower than expected, prompting a need for better predictive models.
  • Researchers optimized the vaccine dose in ferret models and used clinically relevant outcomes, focusing on virus shedding and fever rather than just serum immunogenicity.
  • The study found that LAIV formulations with higher vaccine efficacy showed significantly better protection against H1N1 challenges, highlighting the importance of dosing and endpoint selection in evaluating vaccine effectiveness.
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