Persistent Beta-Blocker Therapy Reduces Long-Term Mortality in Patients With Acute Ischemic Stroke With Elevated Heart Rates.

Background: Elevated heart rate in patients with acute ischemic stroke is associated with increased risk of mortality. Beta-blocker therapy is well known to reduce heart rate.

Methods And Results: This study was a post hoc analysis of patients with acute ischemic stroke with maximum heart rates ≥100 bpm.

Proceedings of the 12th annual deep brain stimulation think tank: cutting edge technology meets novel applications.

The Deep Brain Stimulation (DBS) Think Tank XII was held on August 21st to 23rd. This year we showcased groundbreaking advancements in neuromodulation technology, focusing heavily on the novel uses of existing technology as well as next-generation technology. Our keynote speaker shared the vision of using neuro artificial intelligence to predict depression using brain electrophysiology.

Augmenting the human interactome for disease prediction through gene networks inferred from human cell atlas.

Gene co-expression network inference from bulk tissue samples often misses cell-type-specific interactions, which can be detected through single-cell gene expression data. However, the noise and sparsity of single-cell data challenge the inference of these networks. We developed scNET, a framework for integrative cell-type-specific co-expression network inference from single-cell transcriptome data, demonstrating its utility in augmenting the human interactome for more accurate disease gene prediction.

Methods to optimize the collection, pretreatment, extraction, separation, and examination of microplastics in soil, groundwater, and human samples.

Microplastics (MPs) in soil, groundwater, and human (SGH) present a significant global challenge due to their ecological and human health impacts. However, current protocols for detecting MPs in these environments and humans are limited, inconsistently applied, and vary significantly, particularly during the pretreatment stages of MP analysis. Moreover, no study has investigated the impact of methodological flaws on MP detection.