Publications by authors named "J H Carrozza"
Introduction: The maximal allowable contrast dose (MACD = 5 × body weight/serum creatinine) is an empiric equation that has been used and validated in several studies to mitigate the risk of contrast-induced acute kidney injury (CI-AKI). However, coefficient 5 (referred to as factor K) was empirically devised and never disputed. The aim of this study was to refine the MACD equation for the prediction of CI-AKI following percutaneous coronary interventions (PCIs).
View Article and Find Full Text PDFNative coronary artery thrombosis in the setting of heparin-induced thrombocytopenia: a case report.
Eur Heart J Case Rep
December 2018
Background: Heparin-induced thrombocytopenia (HIT) is a rare complication of heparin therapy. Its pathogenesis includes thrombotic events that can rarely affect the coronary arteries.
Case Summary: We report a 67-year-old woman who presented with extensive lower extremities deep venous thrombosis.
Article Synopsis
- The study evaluates the effectiveness of the non-hyperaemic pressure ratio (NHPR) in assessing coronary stenosis without the need for hyperemic conditions, comparing it to the established method of fractional flow reserve (FFR).
- The analysis of data from 700 patients revealed that an NHPR cutoff of 0.93 accurately predicts significant lesions with an overall diagnostic accuracy of approximately 78.84%.
- The findings suggest that NHPR may be a useful alternative in specific clinical situations, though FFR remains the gold standard when hyperemia can be induced or is clinically indicated.
Purpose Of The Review: Coronary artery disease is a major cause of mortality and morbidity in the world, and PCI and CABG account for over a million procedures performed annually in the USA. The goal of percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG) is to achieve complete revascularization (CR) if at all possible. However, restenosis and stent thrombosis (ST) remain the Achilles heel of contemporary PCI with restenosis rates between 10 and 30% with bare metal stents to 5-15% after drug-eluting stents and ST rates of around 0.
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