Publications by authors named "J H Boss"
To present a case of a young adult with bilateral chronic posterior uveitis resulting from Vogt-Koyanagi-Harada (VKH) disease treated with mycophenolate mofetil who subsequently developed vitreoretinal lymphoma in the right eye. A case and its findings were analyzed. A 34-year-old Hispanic woman presented with an 8-year history of chronic recurrent posterior uveitis in both eyes secondary to VKH disease.
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- - Antibodies are generated by naive B cells turning into plasma cells in germinal centers (GCs) of lymphoid tissues, and patients with B cell lymphoma undergoing immunotherapy have reduced antibody production, leading to higher infection rates and weaker vaccine responses.
- - Current research models struggle to effectively mimic long-term GC functions and assess B cell responses, prompting the development of synthetic hydrogels that replicate the lymphoid tissue environment to support human GCs from various blood sources.
- - The new immune organoid systems maintain critical B cell functions longer and offer unique immune programming features; however, they show less effectiveness with lymphoma-derived B cells, indicating a rapid method for studying immune responses and B cell-related disorders.
Background: Accurate longitudinal risk prediction for DCI (delayed cerebral ischemia) occurrence after subarachnoid hemorrhage (SAH) is essential for clinicians to administer appropriate and timely diagnostics, thereby improving treatment planning and outcome. This study aimed to develop an improved longitudinal DCI prediction model and evaluate its performance in predicting DCI between day 4 and 14 after aneurysm rupture.
Methods: Two DCI classification models were trained: (1) a static model based on routinely collected demographics and SAH grading scores and (2) a dynamic model based on results from laboratory and blood gas analysis anchored at the time of DCI.
PD-1 is a key negative regulator of CD8 T cell activation and is highly expressed by exhausted T cells in cancer and chronic viral infection. Although PD-1 blockade can improve viral and tumor control, physiological PD-1 expression prevents immunopathology and improves memory formation. The mechanisms driving high PD-1 expression in exhaustion are not well understood and could be critical to disentangling its beneficial and detrimental effects.
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- This study investigates the genetic, phenotypic, and environmental factors that contribute to amyotrophic lateral sclerosis (ALS) using data from the UK Biobank, focusing on understanding their joint predictive abilities.
- Researchers created two polygenic risk scores (PRS) to gauge ALS risk, performed phenome-wide association studies (PheWAS) for identifying pre-existing conditions, and developed a poly-exposure score (PXS) for environmental impacts.
- Results showed that the combined PRS and PheRS improved ALS prediction accuracy, indicating that individuals in the top 10% risk score had a significantly higher likelihood of developing ALS compared to those with mid-range scores.