Publications by authors named "J H BARNARD"

Evening consumption of a whey protein rich in the amino acid tryptophan, alpha-lactalbumin (ALAC), has previously shown to benefit sleep-particularly among poor sleepers. Given trained populations often experience sleep difficulty, this study investigated whether evening supplementation of ALAC would influence sleep outcomes, mood, and next-day cognitive performance within a trained population with sleep difficulties. Nineteen trained participants (females, n = 11) with sleep difficulties (Athlete Sleep Screening Questionnaire: 8.

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Background: Despite advances in ablation and other therapies for AF, progression of atrial fibrillation (AF) remains a significant clinical problem, associated with worse prognosis and worse treatment outcomes. Upstream therapies targeting inflammatory or antifibrotic mechanisms have been disappointing in preventing AF progression, but more recently genetic and genomic studies in AF suggest novel cellular and metabolic stress targets, supporting prior studies of lifestyle and risk factor modification (LRFM) for AF. However, while obesity is a significant risk factor, weight loss and risk factor modification have not been successfully applied in a US population with AF.

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Alterations of mitochondrial bioenergetics and arginine metabolism are universally present and mechanistically linked to pulmonary arterial hypertension (PAH), but there is little knowledge of arginine metabolism and mitochondrial functions across the different pulmonary hypertension (PH) groups. We hypothesize that abnormalities in mitochondrial functions are present across all PH groups and associated with clinical phenotypes. We test the hypothesis in PH patients and healthy controls from the Pulmonary Vascular Disease Phenomics Program cohort, who had comprehensive clinical phenotyping and follow-up for at least 4 years for death or transplant status.

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Article Synopsis
  • Atrial fibrillation (AF) often recurs after catheter ablation, and the study investigates how changes in the pulmonary vein (PV) structure, highlighted by artificial intelligence (AI), relate to this recurrence.* -
  • Two AI models were used to analyze CT images from 809 patients, examining features of primary and secondary PV branches to determine their link to AF recurrence post-ablation.* -
  • The findings suggest that morphological features of primary PV branches have a significant association with AF recurrence, indicating potential pathways for improving patient outcomes after ablation.*
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Article Synopsis
  • Complex oxide thin films are essential for various electronic and optical devices, typically requiring high-quality single crystalline substrates like SrTiO (STO) for growth.
  • Recent advancements allow for the transfer of these films as free-standing structures, enabling the integration of complex oxides into other devices and promoting the recycling of the original substrates for cost-effective and sustainable production.
  • The study reveals that recycled STO substrates can influence the microstructure and properties of subsequently grown oxide films, potentially enhancing their characteristics, as seen with improved ferromagnetic responses in yttrium iron garnet films when grown on recycled STO compared to pristine substrates.
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