Publications by authors named "J H Abernathy"
Objective: The incidence of splanchnic vein thrombosis (SVT) is reported to be <25 times lower than that of deep vein thrombosis and pulmonary emboli, which occur in 70 to 270/100,000 cases in the general population. Current guidelines recommend initial treatment with therapeutic low-molecular-weight heparin followed by a transition to a vitamin K antagonist (VKA) or a direct oral anticoagulant (DOAC) in patients with cirrhosis who develop SVT without severe liver dysfunction. This, however, is based on observational data.
View Article and Find Full Text PDFThe catfish industry is the largest sector of U.S. aquaculture production.
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- - Several fish species face economic losses in aquaculture due to infection by a harmful bacteria called Aeromonas hydrophila, leading to the research and isolation of a novel bacteriophage named AhFM11 that targets this bacteria.
- - AhFM11 was found to effectively lyse hypervirulent strains of Aeromonas and has a genome size of 168,243 bp without any antibiotic resistance genes, categorizing it under the Straboviridae family.
- - The application of AhFM11 in treating infection in fish demonstrated high survival rates, suggesting its potential as a safe alternative to antibiotics for controlling bacterial infections in aquaculture.
Background: Improving survival for patients diagnosed with metastatic disease and overcoming chemoresistance remain significant clinical challenges in treating breast cancer. Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by a lack of therapeutically targetable receptors (ER/PR/HER2). TNBC therapy includes a combination of cytotoxic chemotherapies, including microtubule-targeting agents (MTAs) like paclitaxel (taxane class) or eribulin (vinca class); however, there are currently no FDA-approved MTAs that bind to the colchicine-binding site.
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