Publications by authors named "J H Aberle"
Impaired immune response to COVID-19 (coronavirus disease 2019) vaccination has been reported in patients with inborn errors of immunity (IEI). Repetitive vaccinations are recommended for this vulnerable group. Due to the high diversity within IEI patients, additional safety and immunogenicity data are needed to better understand these aspects especially in less common immunodeficiency syndromes.
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- Tick-borne encephalitis virus (TBEV), spread through tick bites, mostly causes mild illness in over 90% of cases, but can lead to varying degrees of encephalitis in some individuals.
- Around 10% of patients with severe TBE in Austria, Czech Republic, and France have auto-antibodies (auto-Abs) that neutralize certain types of interferon (IFN), which are important for immune response, while only about 1% of patients with milder symptoms have them.
- The presence of these auto-Abs significantly increases the risk of severe TBE, with odds ratios indicating up to a 20.8 times higher chance of severe illness when these auto-Abs are
The ubiquitous Torque teno virus (TTV) establishes a chronically persistent infection in the human host. TTV has not been associated with any apparent disease, but, as part of the human virome, it may confer a regulatory imprint on the human immune system with as yet unclear consequences. However, so far, only few studies have characterized the TTV-specific immune responses or the overall immunological imprints by TTV.
View Article and Find Full Text PDFBlood plasma viscosity (PV) is an established biomarker for numerous diseases. Measurement of the shear PV using conventional rheological techniques is, however, time consuming and requires significant plasma volumes. Here, we show that Brillouin light scattering (BLS) and angle-resolved spectroscopy measurements of the longitudinal PV from microliter-sized plasma volumes can serve as a proxy for the shear PV measured using conventional viscometers.
View Article and Find Full Text PDFSARS-CoV-2 Omicron lineages continue to emerge and evolve into new sublineages, causing infection waves throughout 2022 and 2023, which has been attributed to immune escape. We examined neutralizing antibody responses to the recently emerged SARS-CoV-2 JN.1 variant in comparison to ancestral D614G and Omicron BA.
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