Publications by authors named "J Gurunathan"
Article Synopsis
- Snake bites pose a significant risk in tropical regions, prompting research into potential treatments.
- In this study, a compound called naringenin was isolated from Citrus reticulata and shown to significantly inhibit key harmful effects of Naja naja venom, specifically PLA and hemolytic activity.
- The findings support the potential use of Citrus reticulata metabolites as a supplementary treatment option for snake envenomations.
Ethnopharmacological Relevance: Snakebite is a severe problem in many parts of the world, specifically in tropical and subtropical regions. A range of medicinal plant extracts are administered for treating snake bite. Of the many common plants, extracts of Citrus species have been documented to be used for treating snake bite and have been shown to decrease the snake venom toxicity.
View Article and Find Full Text PDFMicroorganisms that survive in the high salt environment have been shown to be a potential source for metabolites with pharmaceutical importance. In the present study, we have investigated the effect of 5 and 10% (w/v) NaCl on growth, biochemical changes, and metabolite production in seven moderately halophilic bacteria isolated from the salterns/mangrove area of South India. Metabolite production by Bacillus VITPS3 increased by 3.
View Article and Find Full Text PDFAsthma is a chronic disease of the airways affecting a large number of people across the globe. Uncontrolled asthma poses an emotional as well as the physical burden on patients and results in a great economic burden. "Exacerbation-prone phenotype" asthmatics are a cluster of patients who may suffer from more frequent and severe exacerbations than other asthmatics.
View Article and Find Full Text PDFContext: The bulb of Allium sativum Linn (Alliaceae) has numerous medicinal values. Though the petroleum ether extract of the bulb has shown to exhibit antimycobacterial activity, the phytochemical(s) responsible for this inhibitory activity is not known.
Objective: To characterize the bioactive compounds in the petroleum ether extract of Allium sativum (garlic) that inhibit the growth of Mycobacterium tuberculosis H37Ra.