Publications by authors named "J Guadagno"
Background: The brain reserve hypothesis posits that larger maximal lifetime brain growth (MLBG) may confer protection against physical disability in multiple sclerosis (MS). Larger MLBG as a proxy for brain reserve, has been associated with reduced progression of physical disability in patients with early MS; however, it is unknown whether this association remains once in the secondary progressive phase of MS (SPMS). Our aim was to assess whether larger MLBG is associated with decreased physical disability progression in SPMS.
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- This study analyzes the effects of immune checkpoint inhibitors (ICIs) on liver transplant outcomes for patients with hepatocellular carcinoma (HCC), focusing on allograft rejection, recurrence, and survival rates.* -
- Out of 91 patients studied, 26.4% experienced allograft rejection, with age and the length of ICI washout being significant risk factors; there were no differences in overall survival between patients with and without rejection.* -
- The findings suggest that with a proper washout period of around 3 months, the risk of allograft rejection may be comparable to patients not exposed to ICIs, indicating that further research is needed to validate these results.*
Background: Over 80% of individuals with multiple sclerosis (MS) experience MS-associated spasticity (MSS). In many European countries, after failure of first-line treatments, moderate or severe MSS can be treated with nabiximols, a cannabis-based add-on treatment.
Objective: This analysis assessed the shift of participants treated with nabiximols from higher (severe or moderate) to lower (moderate or mild/none) spasticity.
Article Synopsis
- Checkpoint inhibitors (CPI) have improved survival rates for various cancers, and this study focused on their effectiveness in patients with poorly differentiated gastrointestinal cancers.
- A total of 123 patients were analyzed, revealing that most had late-stage disease and that poorly differentiated tumors were linked to shorter overall survival compared to well-differentiated tumors.
- Although the study found no significant differences in progression-free survival across tumor types, moderately differentiated tumors were associated with significantly longer overall survival.