Publications by authors named "J Growdon"
Background And Objectives: Alzheimer disease (AD) copathologies of β-amyloid and tau are common in the Lewy body diseases (LBD), dementia with Lewy bodies (DLB) and Parkinson disease (PD), and target distinct hippocampal subfields compared with Lewy pathology, including subiculum and CA1. We investigated the hypothesis that AD copathologies impact the pattern of hippocampal subregion volume loss and cognitive function in LBD.
Methods: This was a cross-sectional and longitudinal, single-center, observational cohort study.
Article Synopsis
- The study aimed to understand the complex features and comorbidities associated with Parkinson's disease by analyzing 933 patients and 291 controls, highlighting the need for a comprehensive approach instead of isolated evaluations.
- Significant associations were found between Parkinson’s disease and conditions like depression, anxiety, sleep apnea, and restless leg syndrome, with higher prevalence observed in patients compared to controls.
- Environmental factors such as pesticide exposure and head trauma were linked to the disease, while a notable proportion of patients also reported using vitamin supplements like cholecalciferol and coenzyme Q10 more than the control group.
Article Synopsis
- - The study addresses the issue of limited ancestral diversity in genome-wide association studies (GWAS), which makes it hard to find genetic risk variants in non-European ancestry groups, focusing on Alzheimer's Disease (AD).
- - Researchers analyzed a multi-ancestry GWAS dataset within the Alzheimer's Disease Genetics Consortium (ADGC) involving individuals from various ancestries, identifying 13 shared risk loci and 3 ancestry-specific loci, highlighting the benefits of diverse samples.
- - The findings underscore the importance of including underrepresented populations in genetic research, suggesting that even smaller sample sizes can lead to the discovery of novel genetic variants related to AD and implicating specific biological pathways like amyloid regulation and neuronal development.
Article Synopsis
- The study investigates how genetic factors affect the progression of Parkinson's disease (PD) to dementia, which significantly impacts patients' quality of life.
- A genome-wide survival analysis was conducted on 3,821 PD patients, uncovering RIMS2 as a key genetic locus linked to disease progression, along with suggestive evidence for TMEM108 and WWOX.
- While polygenic scores related to progression show a strong association with dementia risk, susceptibility scores do not predict outcomes, highlighting different genetic mechanisms for PD progression versus susceptibility.
Multiple neuropathological processes can manifest in life as a corticobasal syndrome. We sought to relate retention of the tau-PET tracer 18F-AV-1451 and structural magnetic resonance measures of regional atrophy to clinical features in clinically diagnosed and neuropathologically confirmed cases of corticobasal syndrome and to determine whether these vary with the underlying neuropathological changes. In this observational, cross-sectional study, 11 subjects (eight female and three male, median age 72 years) with corticobasal syndrome underwent structural MRI, tau-PET with 18F-AV-1451, amyloid-PET with 11C-Pittsburgh compound B, detailed clinical examinations and neuropsychological testing.
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