Patterns of allometric and heterochronic changes in the early ontogeny of species of Physalaemus (Anura: Leptodactylidae).

We studied the relationship between shape, size, and developmental time in the embryonic ontogeny of 15 species of the frog genus Physalaemus. As in other anuran exotrophic embryos, shape changes are correlated with size increase and mainly concern tail elongation, decrease in body height, and increase in fin height. Size ranges and developmental times vary interspecifically.

Transverse aortic constriction multi-omics analysis uncovers pathophysiological cardiac molecular mechanisms.

Time-course multi-omics data of a murine model of progressive heart failure (HF) induced by transverse aortic constriction (TAC) provide insights into the molecular mechanisms that are causatively involved in contractile failure and structural cardiac remodelling. We employ Illumina-based transcriptomics, Nanopore sequencing and mass spectrometry-based proteomics on samples from the left ventricle (LV) and right ventricle (RV, RNA only) of the heart at 1, 7, 21 and 56 days following TAC and Sham surgery. Here, we present Transverse Aortic COnstriction Multi-omics Analysis (TACOMA), as an interactive web application that integrates and visualizes transcriptomics and proteomics data collected in a TAC time-course experiment.

A Low Cost and Eco-Sustainable Device to Determine the End of the Disinfection Process in SODIS.

The lack of safe drinking water is one of the main health problems in many regions of the world. In order to face it, Solar water disinfection (SODIS) proposes the use of transparent plastic containers, which are filled with contaminated water, and exposed to direct sunlight until enough UV radiation is received to inactivate the pathogens. However, a reliable method for determining the end of the disinfection process is needed.

Teaching cancer imaging in the era of precision medicine: Looking at the big picture.

The role of imaging in cancer diagnosis and treatment has evolved at the same rapid pace as cancer management. Over the last twenty years, with the advancement of technology, oncology has become a multidisciplinary field that allows for researchers and clinicians not only to create individualized treatment options for cancer patients, but also to evaluate patients' response to therapy with increasing precision. Familiarity with these concepts is a requisite for current and future radiologists, as cancer imaging studies represent a significant and growing component of any radiology practice, from tertiary cancer centers to community hospitals.

Levels of seminal tRNA-derived fragments from normozoospermic men correlate with the success rate of ART.

Decreased fertility is becoming an important social and medical problem and the male factor is involved in at least half of infertility cases. Since conventional semen analysis provides limited prediction of male fertility; in this work, we evaluated the potential use of seminal small RNAs (sRNA) as markers of semen quality in ART. Our bioinformatic analyses of available sRNA-seq databases showed that the most abundant sRNA species in seminal plasma of normozoospermic men are tRNA-derived fragments (tRFs), a novel class of regulatory sRNAs.