Publications by authors named "J Grooms"
Background: Despite higher dementia prevalence in racial and ethnic minoritized communities, they are underrepresented in Alzheimer's disease clinical trials. Community-based recruitment strategies are believed to yield positive outcomes in various fields, such as cancer and cardiovascular clinical trials, but their outcomes in Alzheimer's disease and Related Dementias (AD/ADRD) require further study. In this systematic rapid review, we synthesized the available evidence on community-engaged recruitment strategies in enhancing participation in AD/ADRD clinical trials and observational study participation.
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- Fragile X syndrome (FXS) is caused by hypermethylation of CGG repeats in the FMR1 gene, resulting in loss of FMRP, which is crucial for normal neuronal function.
- Research has shown that FMRP loss leads to abnormal synaptic activity and hyperexcitability in neurons, but effective treatments have yet to be found due to translation issues from animal models to humans.
- A new high-resolution all-optical electrophysiology platform has been developed to create a sensitive assay that measures FMRP re-expression and healthy neuron restoration, which can be used to identify potential new therapies for FXS.
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- Chronic pain from osteoarthritis (OA) is difficult to treat, necessitating new models to understand its biology and develop effective therapies.
- Researchers created an in vitro model using dorsal root ganglion (DRG) sensory neurons sensitized by an inflammatory cocktail called SPARC, showing that these components can lead to pain responses.
- The study involved high-throughput optical electrophysiology to analyze the effects of approximately 3,000 drugs on the OA-SPARC-induced pain phenotype, highlighting the potential of the Raf-MEK-ERK signaling pathway in DRG neurons as a target for new analgesic treatments.
Evidence is emerging of the pandemic disproportionately impacting communities of color. This study investigates mental health distress among essential workers during the coronavirus pandemic across race and ethnicity. We evaluate individual responses to the patient health questionnaire and general anxiety disorder questionnaire using a unique, nationally representative data set.
View Article and Find Full Text PDFOptogenetic assays provide a flexible, scalable, and information rich approach to probe compound effects for ion channel drug targets in both heterologous expression systems and associated disease relevant cell types. Despite the potential utility and growing adoption of optogenetics, there remains a critical need for compatible platform technologies with the speed, sensitivity, and throughput to enable their application to broader drug screening applications. To address this challenge, we developed the Swarm, a custom designed optical instrument for highly parallelized, multicolor measurements in excitable cells, simultaneously recording changes in voltage and calcium activities at high temporal resolution under optical stimulation.
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