ELEVATED CIRCULATING ENDOTHELIAL CELL-DERIVED MICROVESICLES: A BIOMARKER OF ENDOTHELIAL VASOMOTOR DYSFUNCTION IN ADULTS WITH OBESITY.

Endothelial cell-derived extracellular microvesicles (EMVs) have emerged as a biomarker of cardiovascular disease risk, progression and severity. The aims were to determine: 1) if circulating EMV levels are elevated in adults with obesity; and 2) whether circulating EMVs are associated with obesity-related endothelial vasomotor dysfunction. Thirty-six sedentary, midlife adults (45-63 years) were studied: 18 adults with normal weight (12M/6F; age: 56±6 yr; BMI: 23.

Early, very high-titre convalescent plasma therapy in clinically vulnerable individuals with mild COVID-19: an international, randomised, open-label trial.

Background: COVID-19 convalescent plasma (CCP) is a treatment option for COVID-19. This study investigated the safety and efficacy of early, very high-titre CCP in immunocompromised individuals with mild COVID-19.

Methods: This randomised, controlled, open-label trial assessed CCP in immunocompromised patients (n = 120) with mild COVID-19 in 10 clinical trial centres across Germany, France, and the Netherlands.

The P Spectral Modulus (PSM) as an Assay of Metabolic Status.

The phosphorus-31 (P) spectral modulus (PSM) is a measure of the metabolic status of cells, tissues, and organs. The PSM can be calculated from P nuclear magnetic resonance (P NMR) spectra obtained from cell, tissue, or organ preparations. These P NMR spectra can be a measure of intact living cells, tissues, or organs, or appropriate biochemical extracts of such preparations.

Opioid Use Prior to Arthroscopic Rotator Cuff Repair is Associated with Inferior Patient Reported Outcomes and Lower Rates of Achieving Patient Acceptable Symptom State in the Early Postoperative Period.

Introduction: Preoperative opioid use is a risk factor for complications and diminished outcomes following rotator cuff repair (RCR). The purpose of this study was to evaluate the influence of preoperative opioid use on clinically relevant parameters of patient reported outcomes (PROs) following RCR.

Methods: A consecutive series of patients undergoing arthroscopic RCR from 2018 to 2020 were included.

Rationale and design of APOLLO: a personalized rehAbilitation PrOgram in aLLOgeneic bone marrow transplantation.

Background: Hematopoietic stem cell transplantation (HSCT) is a common therapy for many hematologic malignancies. While advances in transplant practice have improved cancer-specific outcomes, multiple and debilitating long term physical and psychologic effects remain. Patients undergoing allogeneic bone marrow transplantation (allo-BMT) are often critically ill at initial diagnosis and with necessary sequential treatments become increasingly frail and deconditioned.