Publications by authors named "J Grein"
Article Synopsis
- The study investigates the challenges and feasibility of performing CPR on patients with viral hemorrhagic fevers (VHF), highlighting the need for clearer guidelines in critical care interventions.
- Using simulation, the researchers found that CPR can be effectively performed in full PPE, achieving a chest compression fraction of 72% and a manual rate of 129 compressions per minute.
- The study identified various latent safety threats (LSTs) that impact the healthcare team’s safety and performance, suggesting that refining team roles and responsibilities could enhance both safety and CPR quality.
In a survey of 104 US infectious disease specialists, 88% reported working in facilities that allow animal-assisted activities or pet visitation. Variability existed in the species of animals allowed, restricted areas, and veterinary assessments, demonstrating a need to standardize infection prevention approaches across health care facilities to mitigate potential risks.
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- V937 is a genetically unmodified coxsackievirus A21 strain that targets and destroys cancer cells overexpressing ICAM-1, showing promise in treating advanced solid tumors like metastatic melanoma when used alone or with the anti-PD-1 antibody pembrolizumab.
- In preclinical studies, V937 exhibited minimal immune response when used independently, but significantly boosted proinflammatory cytokine production and immune activation when tumor cells were co-cultured with immune cells.
- The study highlights that combining V937 with interferon-gamma and pembrolizumab enhances ICAM-1 expression, further improving the virus's ability to kill tumors and activate immune responses, indicating a potential new treatment strategy for cancers that typically evade immune
MASH is a prevalent liver disease that can progress to fibrosis, cirrhosis, hepatocellular carcinoma (HCC), and ultimately death, but there are no approved therapies. Leukotriene B4 (LTB4) is a potent pro-inflammatory chemoattractant that drives macrophage and neutrophil chemotaxis, and genetic loss or inhibition of its high affinity receptor, leukotriene B4 receptor 1 (BLT1), results in improved insulin sensitivity and decreased hepatic steatosis. To validate the therapeutic efficacy of BLT1 inhibition in an inflammatory and pro-fibrotic mouse model of MASH and fibrosis, mice were challenged with a choline-deficient, L-amino acid defined high fat diet and treated with a BLT1 antagonist at 30 or 90 mg/kg for 8 weeks.
View Article and Find Full Text PDFAssessing past versus present severe acute respiratory coronavirus virus 2 (SARS-CoV-2) infection: A survey of criteria for discontinuing precautions in asymptomatic patients testing positive on admission.
Infect Control Hosp Epidemiol
February 2024
Infection prevention program leaders report frequent use of criteria to distinguish recently recovered coronavirus disease 2019 (COVID-19) cases from actively infectious cases when incidentally positive asymptomatic patients were identified on routine severe acute respiratory coronavirus virus 2 (SARS-CoV-2) polymerase chain reaction (PCR) testing. Guidance on appropriate interpretation of high-sensitivity molecular tests can prevent harm from unnecessary precautions that delay admission and impede medical care.
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