Publications by authors named "J Gregory Dolan"
Background: Oral cancer causes intense pain at the primary site, and such pain can impair oral functions. However, the underlying mechanisms for oral cancer pain are still not fully understood. In the present study, it is investigated whether programmed cell death protein 1 (PD-1) is involved in the development of oral cancer pain.
View Article and Find Full Text PDFPurpose: Data informing the safety, efficacy, treatment logistics, and dosimetry of stereotactic body radiation therapy (SBRT) for lung tumors has primarily been derived from patients with favorably located solitary tumors. SBRT is now considered a standard-of-care treatment for inoperable early-stage non-small cell lung cancer and lung metastases, and therefore extrapolation beyond this limited foundational patient population remains an active source of interest.
Methods And Materials: This case-based discussion provides a practical framework for delivering SBRT to challenging, yet frequently encountered, cases in radiation oncology.
Article Synopsis
- Oral cancer causes significant pain linked to the activation of protease-activated receptor 2 (PAR) in cancer cells and neurons, contributing to nociception (pain sensation).
- Researchers found that inhibiting PAR using nanoparticles to deliver the drug AZ3451 is more effective in reversing pain compared to the drug alone, especially in mouse models of oral cancer pain.
- The study also shows that both the overexpression of the F2RL1 gene in cancer cells and neurons plays a role in pain, and targeting PAR could improve pain management and oral function for patients.
Haeckel's 'art book', Kunstformen der Natur, is likely familiar to most protistologists as it is probably Haeckel's best known work, and it prominently featured protists. No doubt many of us have used some of the images from it in our lectures. Most familiar are perhaps the often-reproduced images of nassularian radiolaria, but plates were also devoted to phaeodarians, acantharia, foraminifera, ciliates, diatoms, dinoflagellates and desmids.
View Article and Find Full Text PDFPurpose: To investigate the potential clinical benefits and dose-averaged Linear Energy Transfer (LET) sparing, utilizing proton arc plan for hepatocellular carcinoma (HCC) patients in comparison with Intensity Modulated Proton Therapy (IMPT).
Methods: Ten HCC patients have been retrospectively selected. Two planning groups were created: Proton Arc plans using Monaco ver.