Publications by authors named "J Granton"
Background: Pulmonary embolism (PE) is an important cause of death and disability. Advances in catheter-directed therapies have led to the use of devices, such as the Inari FlowTriever and Penumbra Indigo system for aspiration thrombectomy (AT) for both massive and sub-massive PE. However, limited data exist on causes of procedural mortality.
View Article and Find Full Text PDFArticle Synopsis
- - This study investigates how the medications propofol and fentanyl behave in the body (PK/PD) in patients using veno-venous extracorporeal membrane oxygenation (V-V ECMO) due to a lack of existing data in this area.
- - Conducted at Toronto General Hospital ICU, the research involved 11 patients monitored over a median of 146 hours, revealing that both medications follow a two-compartment model for clearance and that over-sedation was common despite increased clearance rates shortly after ECMO began.
- - Results show that while clearance of sedatives increased temporarily after ECMO initiation and differences were noted based on sex, sedation effectiveness varied and respiratory effort was inconsistent regardless of medication levels.
Introduction: Limited data exist on therapeutic ranges for newer antimicrobials in the critically ill, with few pharmacokinetic studies including patients undergoing renal replacement therapy or extracorporeal membrane oxygenation (ECMO).
Case Representation: These interventions can potentially alter the pharmacokinetic profile of antibiotics, resulting in therapeutic failures, antimicrobial resistance, or increased toxicity. In this report, we present two ECMO patients treated with cefiderocol and ceftobiprole, where therapeutic drug monitoring (TDM) aided in the successful treatment of severe infections.
Background: Pulmonary rehabilitation (PR) guidelines support the efficacy and safety of supervised exercise training in mild-moderate pulmonary arterial hypertension (PAH). However, the exercise training response and safety of PR in PAH lung transplant (LTx) candidates has not been described.
Objectives: (1) characterize the clinical characteristics and illness trajectory of adult patients with severe PAH listed for LTx and participating in PR; (2) evaluate the change in exercise capacity, aerobic and resistance training volumes; (3) assess PR safety.