Publications by authors named "J Grande"
Background: Maturational failure of dialysis arteriovenous fistulas (AVFs) not uncommonly occurs and is of considerable and timely importance. Our prior studies demonstrate that senescence, a phenotypic process that promotes vascular and other diseases, occurs in the murine AVF. In the present study, we examined whether senescence also occurs in the rat AVF model and the effect of compounds that inhibit or accelerate senescence.
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- Mesenchymal stromal cells (MSC), particularly liver-derived MSC (L-MSC), are shown to have stronger immunomodulatory effects compared to adipose and bone marrow MSC in inhibiting immune cell functions.
- In an experiment using mice with kidney inflammation, various types of MSCs were infused, revealing that while all MSCs improved kidney condition, L-MSC demonstrated superior retention and effectiveness in reducing inflammation and macrophage activity.
- The research highlights the potential of L-MSC as therapeutic agents due to their unique ability to localize inflammation and promote healing, suggesting implications for treating liver-related diseases.
Key Points: Morphometry allows for a more prognostic multidimensional quantification of interstitial fibrosis and tubular atrophy (IFTA) in kidneys than does visual inspection. The density of IFTA foci is determined by dividing the number of contiguous IFTA patches in the kidney cortex by the area of cortex. Higher density of IFTA foci significantly predicted renal allograft failure beyond %IFTA and other biopsy and clinical characteristics.
View Article and Find Full Text PDFBackground: Mesangial expansion (ME) is an understudied histologic lesion in renal allografts. The current Banff score is not reproducible and may miss important ME features. The study aimed to improve the quantification of ME using morphometry, assess changes over time, and determine its association with allograft loss.
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- The study aimed to identify typical clinical and radiological profiles of primary low-grade parotid cancers to improve treatment strategies.
- A retrospective analysis of 57 patients was conducted, reviewing MRI and histopathology results to identify prognostic factors.
- While several positive prognostic factors were identified, the study concluded that a reliable clinical and radiological profile for low-grade cancers could not be established, limiting the ability to tailor more conservative surgical approaches.