Ecosystems globally have reached critical tipping points because of climate change, urbanization, unsustainable resource consumption, and pollution. In response, international agreements have set targets for conserving 30% of global ecosystems and restoring 30% of degraded lands and waters by 2030 (30×30). In 2021, the United States set a target to jointly conserve and restore 30% of US lands and waters by 2030, with a specific goal to restore coastal ecosystems, namely wetlands, seagrasses, coral and oyster reefs, and mangrove and kelp forests, to increase resilience to climate change.
View Article and Find Full Text PDFHerpesviruses, including the oncogenic Epstein-Barr Virus (EBV), must bypass host DNA sensing mechanisms to establish infection. The first viral latency protein expressed, EBNA-LP, is essential for transformation of naïve B cells, yet its role in evading host defenses remains unclear. Using single-cell RNA sequencing of EBNA-LP-Knockout (LPKO)-infected B cells, we reveal an antiviral response landscape implicating the 'speckled proteins' as key restriction factors countered by EBNA-LP.
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