Publications by authors named "J Gout"
Organoid-based precision medicine in pancreatic cancer.
United European Gastroenterol J
November 2024
Pancreatic ductal adenocarcinoma (PDAC) ranks among the leading causes of cancer-related deaths worldwide. Despite advances in precision oncology in other malignancies, treatment of PDAC still largely relies on conventional chemotherapy. Given the dismal prognosis and heterogeneity in PDAC, there is an urgent need for personalized therapeutic strategies to improve treatment response.
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- - Cytidine to Uridine (C-to-U) RNA editing, facilitated by APOBEC1 (A1), plays a crucial role in biological processes, particularly in regulating cholesterol metabolism through editing ApoB mRNA.
- - A1 relies on cofactors like A1CF and RBM47 to form an "editosome" for effective RNA editing, while Syncrip acts as a potential regulator of A1 without directly participating in the editing.
- - The study introduced a new cofactor, RBM46, which enhances A1's editing capabilities on ApoB mRNA and identified novel cellular RNA targets for the A1/RBM46 editosome using advanced sequencing techniques.
Article Synopsis
- Aging leads to the buildup of proteins that behave like amyloid, but how these proteins form isn't fully understood.
- Researchers found that errors in messenger RNA cause amyloid-like proteins to be produced in various human cell types, including stem cells and neurons.
- These errors increase with DNA damage, which is commonly associated with aging, suggesting a connection between normal aging processes and age-related diseases.
Our genome is exposed to a wide variety of DNA-damaging agents. If left unrepaired, this damage can be converted into mutations that promote carcinogenesis or the development of genetically inherited diseases. As a result, researchers and clinicians require tools that can detect DNA damage and mutations with exceptional sensitivity.
View Article and Find Full Text PDFGlyphosate-based weed killers such as Roundup have been implicated in detrimental effects on single- and multicellular eukaryotic model organism health and longevity. However, the mode(s) of action for these effects are currently unknown. In this study, we investigate the impact of exposure to Roundup on two model organisms: Saccharomyces cerevisiae and Caenorhabditis elegans and test the hypothesis that exposure to Roundup decreases transcription fidelity.
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