Publications by authors named "J Gorvel"
Immune evasion strategies of Brucella, the etiologic agent of brucellosis, a global zoonosis, remain partially understood. The omentum, a tertiary lymphoid organ part of visceral adipose tissue, has never been explored as a Brucella reservoir. We report that B.
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- The genus Pseudochrobactrum includes bacteria related to both opportunistic pathogens like Ochrobactrum and the Brucella genus, known for causing the disease brucellosis.
- Recently, strains of Pseudochrobactrum were found in hosts that commonly carry Brucella, leading to potential mix-ups in diagnoses.
- The study of P. algeriensis revealed it has some characteristics similar to Brucella, such as certain lipopolysaccharide traits, but lacks key traits needed for Brucella's pathogenicity, indicating a complex relationship within the Brucellaceae family.
Plasmacytoid dendritic cells (pDC) are the major producer of type 1 IFN in response to TLR7 agonists. Aberrant TLR7 activation and type 1 IFN expression by pDCs are linked to the pathogenesis of certain types of autoimmune diseases, including systemic lupus erythematosus (SLE). This study investigated the underlying mechanisms for TLR7-mediated cytokine expression by pDCs using a late endosome trafficking inhibitor, EGA (4-bromobenzaldehyde -(2,6-dimethylphenyl) semicarbazone).
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- Bacteria from the genus Brucella cause brucellosis, a serious disease affecting both animals and humans, and have been controversially merged with other unrelated bacterial species based on genomic findings.
- Researchers argue this merger is inappropriate due to lack of thorough phylogenetic analysis and exclusion of expert opinions in brucellosis.
- They warn that combining these groups could lead to confusion and risks in public health, particularly impacting those dealing with brucellosis in under-resourced regions, and call for keeping the Brucella genus distinct.