A Randomized, Blinded, Vehicle-Controlled Dose-Ranging Study to Evaluate and Characterize Remdesivir Efficacy Against Ebola Virus in Rhesus Macaques.

Ebola virus (EBOV) causes severe disease in humans, with mortality as high as 90%. The small-molecule antiviral drug remdesivir (RDV) has demonstrated a survival benefit in EBOV-exposed rhesus macaques. Here, we characterize the efficacy of multiple intravenous RDV dosing regimens on survival of rhesus macaques 42 days after intramuscular EBOV exposure.

An Expanded Registry of Candidate cis-Regulatory Elements for Studying Transcriptional Regulation.

Mammalian genomes contain millions of regulatory elements that control the complex patterns of gene expression. Previously, The ENCODE consortium mapped biochemical signals across many cell types and tissues and integrated these data to develop a Registry of 0.9 million human and 300 thousand mouse candidate cis-Regulatory Elements (cCREs) annotated with potential functions .

Type 1 Diabetes Mellitus in Movies: The Hollywood Effect.

Introduction: Type 1 diabetes mellitus (T1D) is one of the most common chronic diseases with childhood onset. Cinematic films and movies can reach populations worldwide and affect their concept of this disease. Through this research, the authors examined the accuracy of movies depicting T1D from childhood into adulthood.

Clinical Instructor Perceptions of Preparedness, Performance, and Professionalism of Doctor of Physical Therapy Students from a 2-Year Hybrid Program: A Mixed Methods Study.

Objective: Doctor of Physical Therapy (DPT) education models vary in length, philosophy, and delivery. The purpose of this study was to explore clinical instructor (CI) perceptions of performance in DPT students from a 2-year hybrid program.

Methods: In this mixed methods phenomenological study, data from eight cohorts of students were examined.