E74-like ETS transcription factor 3 expression and regulation in human intervertebral disc.

Background: Intervertebral disc degeneration (IVDD) is one of the main causes of chronic low back pain. The degenerative process is often initiated by an imbalance between catabolic and anabolic pathways. Despite the large socio-economic impact, the initiation and progress of disc degeneration are poorly understood.

Analysis of cytotoxicity and genotoxicity of diesel exhaust PM2.5 generated from diesel and dual natural gas-diesel engines.

Diesel exhaust particles (DEPs) are atmospheric pollutants associated with adverse health effects. In response to their impact, natural gas (NG) has emerged as a promising alternative fuel due to its cleaner combustion. Although the cytotoxicity and genotoxicity of DEPs from diesel or NG engines have been extensively studied, the impact of dual natural gas-diesel systems remains unexplored.

Stroke severity shapes extracellular vesicle profiles and their impact on the cerebral endothelial cells.

Ischaemic stroke is a leading cause of death and disability. Circulating extracellular vesicles (EVs) post-stroke may help brain endothelial cells (BECs) counter ischaemic injury. However data on how EVs from ischaemic stroke patients, considering injury severity, affect these cells are limited.

Multi-frame x-ray radiography and image tracking for quantification of expansion in laser-driven tin ejecta microjets.

One regime of experimental particle-laden flow study involves ejecta microjets-often defined as a stream of micrometer-scale particles generated through shock interaction with a non-uniform surface and generally travel above 1 km/s. In order to capture the change in characteristics as a function of propagation time, we apply a multi-frame x-ray radiography platform to observe and track the jet transport dynamics. A synchrotron x-ray source allows us to perform quantitative analyses and comparisons between the eight images captured by the imaging system.