A Conserved Di-Lysine Motif in the E2 Transactivation Domain Regulates MmuPV1 Replication and Disease Progression.

The papillomavirus E2 protein regulates the transcription, replication, and segregation of viral episomes within the host cell. A multitude of post-translational modifications have been identified which control E2 functions. A highly conserved di-lysine motif within the transactivation domain (TAD) has been shown to regulate the normal functions of the E2 proteins of BPV-1, SfPV1, HPV-16, and HPV-31.

In Vivo Imaging of Cardiac Attachment of TcI and TcII Variants of in a Zebrafish Model.

, the etiological agent of Chagas disease, is a parasite known for its diverse genotypic variants, or Discrete Typing Units (DTUs), which have been associated with varying degrees of tissue involvement. However, aspects such as parasite attachment remain unclear. It has been suggested that the TcI genotype is associated with cardiac infection, the most common involved site in chronic human infection, while TcII is associated with digestive tract involvement.

Anatomical Total Shoulder Arthroplasty with Keeled glenoids in Patients under 60 years at 10 years minimum: which risk factors of failure are still valid at long term follow-up?

Aim: To assess the long-term (>10 years) outcomes in anatomical total shoulder arthroplasty (aTSA) and implant survival in patient under 60 years and identify risk factors for complications and revision.

Methods: This was a retrospective, multicenter study conducted from 1993 to 2008. Over 104 aTSA, 87 in 82 patients (55 years, 36 to 60yo) were included at a mean follow-up of 14±4 years (10 to 25y).

Development of an Alternative Protocol to Study Muscle Fatigue.

When measuring real-time in vivo muscle fatigue with electromyography (), data collection can be compromised by premature sensor removal or environmental noise; therefore, the objective of this study was to develop a postmortem in vivo methodology to induce muscle fatigue and measure it using EMG. Barrows ( = 20) were stratified by weight and randomly allocated into one of two treatments. The treatments consisted of barrows being subjected to a hog electric stunner super-contraction cycle () or not () postmortem.

Effects of Nicotinamide Riboside Supplementation on Postmortem Mitochondrial Functionality and Apoptotic Activation.

Background/objectives: Early postmortem mitochondrial function and apoptotic activation affect meat quality development. Nicotinamide riboside (NR) supplementation to pigs prior to harvest can improve pork color stability, but its mechanism remains unclear. This study aimed to evaluate the impact of NR supplementation on early postmortem mitochondrial functionality and apoptosis.