Publications by authors named "J Golden"
Murine Models to Study Crimean-Congo Hemorrhagic Fever Hepatic Injury.
Methods Mol Biol
December 2024
Crimean-Congo hemorrhagic fever virus (CCHFV) is a member of the family Nairoviridae in the Hareavirales order and is an important human pathogen. Hepatic injury is a salient feature of CCHF human disease and can be recapitulated in murine models. Here, we described techniques to study liver damage caused by CCHFV in the mouse system.
View Article and Find Full Text PDFA three-step synthesis of anti-amoebic, ring-fused mackinazolinones has been developed. A Mannich-type reaction between quinazolin-4-ones and -Cbz propanal in the presence of AgOTf afforded quinazolinones (19-94% isolated yield) bearing a newly formed heterocycle with an alkylamine appendage that, upon -Cbz deprotection and basification, triggered a domino rearrangement to afford 45 separable, ring-fused products. Several compounds inhibited growth of parasites that can cause a lethal human brain infection.
View Article and Find Full Text PDFAim: Evaluation of ultra-low dose chest CT imaging for the assessment of pectus excavatum severity as determined by pediatric radiologists and pediatric surgeons using Haller (HI) and Correction indices (CI).
Methods: A single institution, prospective evaluation of patients being evaluated for pectus excavatum were scanned with a standard low-dose chest CT protocol (CARE) followed by a consecutive ultra-low dose CT scan (ULTRA). 3 surgeons and 4 radiologists were instructed to determine HI and CI in each series.
Aim: To evaluate factors associated with excellent correction in pectus excavatum patients undergoing vacuum bell therapy (VBT).
Methods: A single-institution retrospective chart review was performed November 2012-April 2023 to assess corrections of patients who underwent VBT. Patient demographics, presentation, and results were collected.
Article Synopsis
- MUC1 peptide vaccines are being studied as a way to boost immunity against colon cancer in individuals with a history of premalignant colon adenomas, and trials showed varied responses among participants.
- Researchers analyzed blood samples from vaccine responders and non-responders to identify potential early biomarkers that could indicate long-term immune memory and reduce adenoma recurrence.
- The study found that MUC1 responders had distinct immune profiles, including higher CD4 cell counts and specific activated pathways, suggesting these factors could help predict who is likely to benefit from the vaccine and assist in developing personalized cancer preventive strategies.