Publications by authors named "J Goikoetxea"
Isavuconazole Versus Voriconazole as the First-line Therapy for Solid Organ Transplant Recipients With Invasive Aspergillosis: Comparative Analysis of 2 Multicenter Cohort Studies.
Transplantation
November 2024
Article Synopsis
- Isavuconazole (ISA) and voriconazole (VORI) are both recommended first-line treatments for invasive aspergillosis, but there hasn't been a direct comparison in solid organ transplant recipients.
- A study analyzed data from two cohorts of patients treated with either ISA or VORI, focusing on clinical response, mortality rates, adverse events, and treatment discontinuation after 12 weeks.
- Results showed no significant difference in clinical outcomes between ISA and VORI, but ISA had fewer adverse events and lower rates of treatment discontinuation, indicating better tolerability.
Mortality impact of further delays in active targeted antibiotic therapy in bacteraemic patients that did not receive initial active empiric treatment: Results from the prospective, multicentre cohort PROBAC.
Int J Infect Dis
August 2024
Objectives: The early initiation of the empirical antibiotic treatment and its impact on mortality in patients with bacteraemia has been extensively studied. However, information on the impact of precocity of the targeted antibiotic treatment is scarce. We aimed to study the impact of further delay in active antibiotic therapy on 30-day mortality among patients with bloodstream infection who had not received appropriate empirical therapy.
View Article and Find Full Text PDFAssociation of microbiological factors with mortality in Escherichia coli bacteraemia presenting with sepsis/septic shock: a prospective cohort study.
Clin Microbiol Infect
August 2024
Objectives: This study aimed to determine the association of Escherichia coli microbiological factors with 30-day mortality in patients with bloodstream infection (BSI) presenting with a dysregulated response to infection (i.e. sepsis or septic shock).
View Article and Find Full Text PDFWhole-genome characterisation of Escherichia coli isolates from patients with bacteraemia presenting with sepsis or septic shock in Spain: a multicentre cross-sectional study.
Lancet Microbe
April 2024
Article Synopsis
- - The study focuses on characterizing *Escherichia coli* (E. coli) blood isolates that cause sepsis or septic shock, as these infections are common and often severe, leading to critical health outcomes in affected patients.
- - Data from a multicenter study in Spain involved whole-genome sequencing of E. coli blood isolates from patients over 14 with diagnosed sepsis or septic shock, identifying various microbiological features, including phylogroups, sequence types, virulence factors, and antimicrobial resistance (AMR) genes.
- - Results showed that most isolates belonged to phylogenetic group 1, with specific sequence types such as ST131 and ST73 being the most common, but there were no significant geographical
Background: Prosthetic valve endocarditis (PVE) is a serious infection associated with high mortality that often requires surgical treatment.
Methods: Study on clinical characteristics and prognosis of a large contemporary prospective cohort of prosthetic valve endocarditis (PVE) that included patients diagnosed between January 2008 and December 2020. Univariate and multivariate analysis of factors associated with in-hospital mortality was performed.