Nucleus accumbens sub-regions experience distinct dopamine release responses following acute and chronic morphine exposure.

Unlabelled: It is well established that dopamine neurons of the ventral tegmental area (VTA) play a critical role in reward and aversion as well as pathologies including drug dependence and addiction. The distinct effects of acute and chronic opioid exposure have been previously characterized at VTA synapses. Recent work suggests that distinct VTA projections that target the medial and lateral shell of the nucleus accumbens (NAc), may play opposing roles in modulating behavior.

Influence of chemical structure of organic micropollutants on the degradability with ozonation.

The increasing environmental problems due to various organic micropollutants in water cause the search of suitable additional water treatment methods. Gaining experimental data for the large amount and variety of pollutants would consume a lot of time as well as economic and ecologic resources. An alternative approach is predictive quantitative structure-property relationship (QSPR) modeling, which establishes a correlation between the structural properties of a molecules with a biological, physical, or chemical property.

Prediction of degradability of micropollutants by sonolysis in water with QSPR - a case study on phenol derivates.

The increasing quantity and variety of organic contaminants discharged into surface and groundwater increase the necessity of additional and suitable water treatment methods, which can be incorporated into existing wastewater treatment plants. The huge variety of micropollutants and local variability of the composition of the organic load or matrix effects paired with multiple possible degradation processes lead to the requirement of a recommendation tool for the best possible water treatment method under given local conditions. Due to the diversity of physicochemical properties of micropollutants, such predictions are challenging.

Magnetic permeability as a predictor of the artefact size caused by orthodontic appliances at 1.5 T magnetic resonance imaging.

Objectives: Artefacts caused by orthodontic attachments limit the diagnostic value and lead to removal of these appliances before magnetic resonance imaging. Magnetic permeability can predict the artefact size. There is no standardised approach to determine the permeability of such attachments.

Hedgehog-interacting protein is highly expressed in endothelial cells but down-regulated during angiogenesis and in several human tumors.

Background: The Hedgehog (Hh) signaling pathway regulates a variety of developmental processes, including vasculogenesis, and can also induce the expression of pro-angiogenic factors in fibroblasts postnatally. Misregulation of the Hh pathway has been implicated in a variety of different types of cancer, including pancreatic and small-cell lung cancer. Recently a putative antagonist of the pathway, Hedgehog-interacting protein (HIP), was identified as a Hh binding protein that is also a target of Hh signaling.